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Articles Published Processes
4/2/2025 10:54:11 AM | Browse: 62 | Download: 382
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Received |
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2024-12-24 05:19 |
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Peer-Review Started |
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2024-12-24 05:19 |
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First Decision by Editorial Office Director |
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2025-02-13 23:28 |
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Return for Revision |
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2025-02-13 23:28 |
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Revised |
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2025-02-25 11:13 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-03-06 02:35 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-03-06 02:58 |
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Articles in Press |
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2025-03-06 02:58 |
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Edit the Manuscript by Language Editor |
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2025-03-09 22:15 |
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Typeset the Manuscript |
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2025-03-24 05:52 |
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Publish the Manuscript Online |
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2025-04-02 10:54 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Targeting mixed lineage kinase domain-like protein's non-necroptosis role: A new horizon in anti-inflammatory therapy for alcoholic liver disease
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yue Xi, Dong Guo, Shi Li, Jie-Yu Guo, Xing-Zhen Chen, Jing-Feng Tang and Ce-Fan Zhou |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ce-Fan Zhou, School of Life and Health Sciences, Institute of Biomedical Research, National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, No. 28 Nanli Road, Wuhan 430068, Hubei Province, China. cefan@hbut.edu.cn |
| Key Words |
Mixed lineage kinase domain-like protein; ATP-binding pocket; CPD4 inhibitor; Alcoholic liver disease; Therapeutic targets; Liver diseases |
| Core Tip |
The mixed lineage kinase domain-like protein (MLKL) ATP-binding pocket inhibitor CPD4 demonstrates significant promise as a novel therapeutic agent for alcoholic liver disease (ALD), providing dual benefits through the reduction of hepatic inflammation and the enhancement of liver function. In this article, we emphasize the regulatory role of CPD4 as a targeted inhibitor of the MLKL ATP-binding pocket and highlight its ability to modulate ALD progression through the NF-κB signaling pathway. Furthermore, future research should explore the potential of combination therapies involving MLKL inhibitors to optimize treatment strategies. These advancements may pave the way for personalized approaches to treating ALD and other related liver diseases. |
| Publish Date |
2025-04-02 10:54 |
| Citation |
Xi Y, Guo D, Li S, Guo JY, Chen XZ, Tang JF, Zhou CF. Targeting mixed lineage kinase domain-like protein's non-necroptosis role: A new horizon in anti-inflammatory therapy for alcoholic liver disease. World J Gastroenterol 2025; 31(13): 104546 |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i13/104546.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i13.104546 |
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