Publication Name	World Journal of Stem Cells
Manuscript ID	104566
Country	China

Received	2024-12-25 10:48
Peer-Review Started	2024-12-27 01:11
To Make the First Decision
Return for Revision	2025-01-16 13:13
Revised	2025-01-21 01:58
Second Decision	2025-02-18 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-02-18 08:30
Articles in Press	2025-02-18 08:30
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-02-22 01:39
Typeset the Manuscript	2025-03-13 08:51
Publish the Manuscript Online	2025-03-21 06:10

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Cell Biology
Manuscript Type	Letter to the Editor
Article Title	Efficacy equivalence but hidden hurdles: Can serum-free human umbilical cord mesenchymal stem cells translate to clinically superior osteoarthritis therapy
Manuscript Source	Invited Manuscript
All Author List	Fang Lin, Ke-Xin Ma, Yue Ding and Xiao-Ting Liang
ORCID	Author(s) ORCID Number Fang Lin http://orcid.org/0000-0001-8008-7764 Yue Ding http://orcid.org/0009-0003-8552-1381 Xiao-Ting Liang http://orcid.org/0000-0003-3262-1859
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Shanghai 24ZR1459300 Pyramid Talent Project YQ677
Corresponding Author	Xiao-Ting Liang, Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Tongji University School of Medicine, No. 150 Jimo Road, Shanghai 200120, China. liangxt@tongji.edu.cn
Key Words	Mesenchymal stem cells; Serum-free culture; Osteoarthritis; Cartilage repair; Regenerative medicine
Core Tip	This article evaluates the study by Xiao et al on using serum-free cultured human umbilical cord mesenchymal stem cells (N-hUCMSCs) to treat knee osteoarthritis in a mouse model. Although N-hUCMSCs matched the efficacy of both serum-cultured hUCMSCs and hyaluronic acid, future research must clarify how N-hUCMSCs differ in long-term proliferative capacity and senescence profiles compared to their serum-cultured counterparts. Additionally, since hyaluronic acid is an established osteoarthritis treatment, demonstrating clear advantages, such as fewer side effects, more durable outcomes, or enhanced cartilage regeneration, will be crucial for justifying the clinical adoption of N-hUCMSCs.
Publish Date	2025-03-21 06:10
Citation	<p>Lin F, Ma KX, Ding Y, Liang XT. Efficacy equivalence but hidden hurdles: Can serum-free human umbilical cord mesenchymal stem cells translate to clinically superior osteoarthritis therapy. <i>World J Stem Cells</i> 2025; 17(3): 104566</p>
URL	https://www.wjgnet.com/1948-0210/full/v17/i3/104566.htm
DOI	https://dx.doi.org/10.4252/wjsc.v17.i3.104566

Full Article (PDF)	WJSC-17-104566-with-cover.pdf
Manuscript File	104566_Auto_Edited_025744.docx
Answering Reviewers	104566-answering-reviewers.pdf
Audio Core Tip	104566-audio.mp3
Conflict-of-Interest Disclosure Form	104566-conflict-of-interest-statement.pdf
Copyright License Agreement	104566-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	104566-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	104566-non-native-speakers.pdf
Peer-review Report	104566-peer-reviews.pdf
Scientific Misconduct Check	104566-scientific-misconduct-check.png
Scientific Editor Work List	104566-scientific-editor-work-list.pdf
CrossCheck Report	104566-crosscheck-report.pdf