Publication Name	World Journal of Experimental Medicine
Manuscript ID	104678
Country	India

Received	2025-01-06 05:25
Peer-Review Started	2025-01-07 02:19
To Make the First Decision
Return for Revision	2025-02-11 08:04
Revised	2025-02-26 11:17
Second Decision	2025-04-09 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-09 08:39
Articles in Press	2025-04-09 08:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-05-08 08:32
Publish the Manuscript Online	2025-08-12 08:18

ISSN	2220-315x (online)
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Category	Biotechnology & Applied Microbiology
Manuscript Type	Minireviews
Article Title	Flavonoids extract from Vitex negundo inhibit autophagy by targeting PI3K/AKT/mTOR/p70S6K/ULK signaling cascade in cancerous cells
Manuscript Source	Invited Manuscript
All Author List	Gunjan Garg, Shweta Chaudhary, Kalpana Khatana and Alok Bharadwaj
ORCID	Author(s) ORCID Number Gunjan Garg http://orcid.org/0000-0002-6971-1981 Shweta Chaudhary http://orcid.org/0009-0000-9727-6414 Kalpana Khatana http://orcid.org/0009-0003-0328-0044 Alok Bharadwaj http://orcid.org/0000-0002-7383-188X
Funding Agency and Grant Number
Corresponding Author	Alok Bharadwaj, Associate Professor, PhD, Department of Biotechnology, GLA University, 17 Km Mile Stone, Mathura-Delhi Highway NH-1, Post-Chaumuhan District, Mathura 281406, Uttar Pradesh, India. alok.bhardwaj@gla.ac.in
Key Words	Cancer; Flavonoids; Inhibitors; Phosphoinositide 3-kinase-protein kinase B-mammalian target of rapamycin; Vitex negundo
Core Tip	We try to emphasize in this medical literature how different signaling pathways contribute to the development of different types of cancer. Anticancer medications are known to target the phosphoinositide 3-kinase-protein kinase B-mammalian target of rapamycin pathway. Vitex negundo (V. negundo) is one of the very crucial plants that have wide packages in traditional structures of medicines. All a part of the plant from root to fruit possess multitude of phytochemicals as secondary metabolites. As discuss above V. negundo is a very good supply of flavonoids. Flavonoids are recommended as anticancer retailers because of their natural assets, price-effectiveness, and ease of use. Their intrinsic properties, such as restricted bioavailability, rapid metabolism, untargeted transport, and cytotoxicity to normal cells, prevent their full clinical potential from being discovered. The efficient use of a combination of flavonoids has been suggested to boost their anticancer efficacy, taking into account the potential to concurrently impact unique signaling cascades. The usage of superior strategies, along with diverse nanotechnology-based methods, is likewise advised to mitigate the stated drawbacks. Incorporating them with current chemotherapeutic tablets could resource in lowering vital doses, in the end main to fewer aspect results.
Publish Date	2025-08-12 08:18
Citation	<p>Garg G, Chaudhary S, Khatana K, Bharadwaj A. Flavonoids extract from Vitex negundo inhibit autophagy by targeting PI3K/AKT/mTOR/p70S6K/ULK signaling cascade in cancerous cells. <i>World J Exp Med</i> 2025; 15(3): 104678</p>
URL	https://www.wjgnet.com/2220-315X/full/v15/i3/104678.htm
DOI	https://dx.doi.org/10.5493/wjem.v15.i3.104678

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