| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
SPDL1 inhibition enhances colorectal cancer progression via epidermal growth factor receptor/extracellular signal-regulated kinase pathways
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Peng Peng, Juan Sun, Meng-Shi Li, Ruo-Xi Cheng, Shi-Quan Liu, Meng-Bin Qin, Jin-Xiu Zhang and Jie-An Huang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Guangxi Province |
No. 2019GXNSFAA185030 |
| Natural Science Foundation of Guangxi Province |
No. 2023GXNSFBA026129 |
| Scientific Research Project of the Second Affiliated Hospital of Guangxi Medical University |
No. EFYKY2020013 |
| Cultivation Science Foundation of The Second Affiliated Hospital of Guangxi Medical University |
No. GJPY2023005 |
| Cultivation Science Foundation of The Second Affiliated Hospital of Guangxi Medical University |
No. GJPY2023009 |
|
| Corresponding Author |
Jie-An Huang, Chief Physician, PhD, Professor, Department of Gastroenterology, The Second Affiliated Hospital of Guangxi Medical University, No. 166 Daxue East Road, Xixiangtang District, Nanning 530007, Guangxi Zhuang Autonomous Region, China. hjagxmu@163.com |
| Key Words |
Colorectal cancer; SPDL1; Epidermal growth factor receptor; Epithelial-mesenchymal transition; Extracellular signal-regulated kinase; Migration; Invasion |
| Core Tip |
The SPDL1 is a gene involved in cell cycle regulation and influences the development of a variety of tumours, including colorectal cancer (CRC). In this study, we investigated the effect of SPDL1 on CRC. We found that interference with SPDL1 expression promoted CRC proliferation, migration and invasion, suggesting that SPDL1 may have a potential tumour suppressor role in CRC by inducing epithelial-mesenchymal transition and by mechanistically targeting the epidermal growth factor receptor/extracellular signal-regulated kinase pathway. |
| Publish Date |
2025-05-15 10:28 |
| Citation |
<p>Peng P, Sun J, Li MS, Cheng RX, Liu SQ, Qin MB, Zhang JX, Huang JA. SPDL1 inhibition enhances colorectal cancer progression via epidermal growth factor receptor/extracellular signal-regulated kinase pathways. <i>World J Gastrointest Oncol</i> 2025; 17(5): 104686</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i5/104686.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i5.104686 |
