Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	104689
Country	Russia

Received	2024-12-31 04:13
Peer-Review Started	2024-12-31 04:13
To Make the First Decision
Return for Revision	2025-03-19 02:54
Revised	2025-04-01 16:31
Second Decision	2025-04-09 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-09 07:59
Articles in Press	2025-04-09 07:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-06-06 08:02
Publish the Manuscript Online	2025-06-16 10:38

ISSN	2219-2808 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Pediatrics
Manuscript Type	Retrospective Cohort Study
Article Title	Analysis of fatal outcomes of patients with mucopolysaccharidosis type II according to the Russian mucopolysaccharidosis registry
Manuscript Source	Invited Manuscript
All Author List	Natalia Buchinskaya, Anastasia Vechkasova, Nato Vashakmadze, Leyla Namazova-Baranova, Dmitry Ivanov, Ekaterina Zakharova, Sergei Kutsev and Mikhail Kostik
ORCID	Author(s) ORCID Number Natalia Buchinskaya http://orcid.org/0000-0002-2335-3023 Anastasia Vechkasova http://orcid.org/0009-0004-8775-9630 Nato Vashakmadze http://orcid.org/0000-0001-8320-2027 Leyla Namazova-Baranova http://orcid.org/0000-0002-2209-7531 Dmitry Ivanov http://orcid.org/0000-0002-0060-4168 Ekaterina Zakharova http://orcid.org/0000-0002-5020-1180 Sergei Kutsev http://orcid.org/0000-0002-3133-8018 Mikhail Kostik http://orcid.org/0000-0002-1180-8086
Funding Agency and Grant Number
Corresponding Author	Mikhail Kostik, MD, PhD, Professor, Hospital Pediatry, Saint-Petersburg State Pediatric Medical University, Lytovskaya 2, Saint-Petersburg 194100, Sankt-Peterburg, Russia. kost-mikhail@yandex.ru
Key Words	Mucopolysaccharidosis type II; IDS gene; Genotype-phenotype; Long-term outcomes; Russian Federation
Core Tip	Mucopolysaccharidosis type II is a rare lysosomal storage disease characterized by the progression of multiorgan dysfunction and increased mortality rates. The assessment of the death outcomes might improve the survival of these patients. High birth weight, delayed diagnosis, delayed enzyme replacement treatment, any signs of central nervous system involvement, and progressive impossibility of independent walking were the main predictors of the fatal outcome.
Publish Date	2025-06-16 10:38
Citation	<p>Buchinskaya N, Vechkasova A, Vashakmadze N, Namazova-Baranova L, Ivanov D, Zakharova E, Kutsev S, Kostik M. Analysis of fatal outcomes of patients with mucopolysaccharidosis type II according to the Russian mucopolysaccharidosis registry. <i>World J Clin Pediatr</i> 2025; 14(3): 104689</p>
URL	https://www.wjgnet.com/2219-2808/full/v14/i3/104689.htm
DOI	https://dx.doi.org/10.5409/wjcp.v14.i3.104689

Full Article (PDF)	WJCP-14-104689-with-cover.pdf
STROBE Statement	104689-STROBE-statement.pdf
Manuscript File	104689_Auto_Edited_015525.docx
Answering Reviewers	104689-answering-reviewers.pdf
Audio Core Tip	104689-audio.m4a
Biostatistics Review Certificate	104689-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	104689-conflict-of-interest-statement.pdf
Copyright License Agreement	104689-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s)	104689-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	104689-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	104689-non-native-speakers.pdf
Peer-review Report	104689-peer-reviews.pdf
Scientific Misconduct Check	104689-scientific-misconduct-check.png
Scientific Editor Work List	104689-scientific-editor-work-list.pdf
CrossCheck Report	104689-crosscheck-report.pdf