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4/25/2025 7:53:57 AM | Browse: 2 | Download: 0
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Received |
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2025-01-02 12:53 |
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2025-01-03 09:02 |
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2025-02-13 02:06 |
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2025-02-20 11:39 |
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2025-03-11 02:45 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-03-11 08:55 |
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Articles in Press |
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2025-03-11 08:55 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-03-26 02:11 |
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Publish the Manuscript Online |
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2025-04-25 07:53 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Review |
| Article Title |
Monogenic diabetes: An evidence-based clinical approach
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Saptarshi Bhattacharya, Cornelius J Fernandez, Abul Bashar Mohammad Kamrul-Hasan and Joseph M Pappachan |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Joseph M Pappachan, MD, Professor, Senior Researcher, Faculty of Science,, Manchester Metropolitan University, All Saints Building, Oxford Road, Manchester M15 6BH, Greater Manchester, United Kingdom. drpappachan@yahoo.co.in |
| Key Words |
Monogenic diabetes; Maturity-onset diabetes of the young; Neonatal diabetes; Mitochondrial diabetes; Insulin resistance syndrome; Monogenic autoimmune diabetes; Next-generation sequencing |
| Core Tip |
Monogenic diabetes is an uncommon form of diabetes caused by single gene mutations. Depending on the type of underlying gene mutation, the disease can present at any age with diverse clinical presentations. The diagnostic workup includes genetic testing and may involve tests like C-peptide assay and autoantibody screening to exclude other forms of diabetes. Next-generation sequencing technologies such as targeted gene panels focusing on known monogenic diabetes genes, and whole-exome sequencing that analyze the protein-coding regions of the genome are replacing older methods like sanger sequencing. Pitfalls in workup can include misdiagnosis as type 1 or type 2 diabetes, leading to inappropriate treatment and potential complications. This evidence-based review updates the current clinical approach to monogenic diabetes. |
| Publish Date |
2025-04-25 07:53 |
| Citation |
<p>Bhattacharya S, Fernandez CJ, Kamrul-Hasan ABM, Pappachan JM. Monogenic diabetes: An evidence-based clinical approach. <i>World J Diabetes</i> 2025; 16(5): 104787</p> |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i5/104787.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i5.104787 |
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