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7/14/2025 12:55:50 PM | Browse: 7 | Download: 22
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 104806
Country Brazil
Received
2025-01-07 08:49
Peer-Review Started
2025-01-07 08:49
To Make the First Decision
Return for Revision
2025-01-18 10:09
Revised
2025-01-23 18:00
Second Decision
2025-02-10 02:33
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2025-02-10 05:45
Articles in Press
2025-02-10 05:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
2025-02-17 14:31
Typeset the Manuscript
2025-03-27 08:25
Publish the Manuscript Online
2025-07-14 12:55
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Letter to the Editor
Article Title Enhancing T-cell response with monoclonal antibodies and chemotherapy in advanced gastric cancer
Manuscript Source Unsolicited Manuscript
All Author List Ana Carolina Pires and Pedro Luiz Serrano Uson Junior
ORCID
Author(s) ORCID Number
Pedro Luiz Serrano Uson Junior http://orcid.org/0000-0001-6122-1374
Funding Agency and Grant Number
Corresponding Author Pedro Luiz Serrano Uson Junior, Assistant Professor, MD, Center for Personalized Medicine, Hospital Israelita Albert Einstein, Avenida Albert Einstein 627, São Paulo 05652900, Brazil. pedro.serrano@einstein.br
Key Words Gastric cancer; Oxaliplatin; Trastuzumab; CD4; CD8
Core Tip After six cycles of treatment with chemotherapy and trastuzumab it was observed that the levels of tumor markers in the blood significantly dropped compared to their initial values. Furthermore, there was a notable increase in the percentages of CD3+ and CD4+ T cells, with the CD4+/CD8+ ratio also increasing after the treatment. Patients who had a reduction of 50% or more in their tumor markers and an increase in the CD4+/CD8+ ratio showed better disease outcomes. These findings can be related to the current field of advancements in the treatment of HER-2 positive gastric cancer, with the combination of immune checkpoint inhibitors.
Publish Date 2025-07-14 12:55
Citation <p>Pires AC, Uson Junior PLS. Enhancing T-cell response with monoclonal antibodies and chemotherapy in advanced gastric cancer. <i>World J Gastrointest Oncol</i> 2025; 17(7): 104806</p>
URL https://www.wjgnet.com/1948-5204/full/v17/i7/104806.htm
DOI https://dx.doi.org/10.4251/wjgo.v17.i7.104806
Full Article (PDF) WJGO-17-104806-with-cover.pdf
Manuscript File 104806_Auto_Edited_083202.docx
Answering Reviewers 104806-answering-reviewers.pdf
Audio Core Tip 104806-audio.m4a
Conflict-of-Interest Disclosure Form 104806-conflict-of-interest-statement.pdf
Copyright License Agreement 104806-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 104806-non-native-speakers.pdf
Peer-review Report 104806-peer-reviews.pdf
Scientific Misconduct Check 104806-scientific-misconduct-check.png
Scientific Editor Work List 104806-scientific-editor-work-list.pdf
CrossCheck Report 104806-crosscheck-report.pdf