| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, General & Internal |
| Manuscript Type |
Basic Study |
| Article Title |
Modulating oral microbiota ameliorates hypobaric hypoxia-induced anxiety- and depression-like behaviors in mice
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wen-Yue Chang, Qiao-Zhen Qin, Xiao-Tong Li, Jia-Jing Wang, Yue Chen, Hua-Qiang Ruan, Yan-Nv Qu, Xiao-Xia Jiang and Hui-Xia He |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Guangdong Basic and Applied Basic Research Foundation |
2023A1515012394 |
|
| Corresponding Author |
Hui-Xia He, Department of Stomatology, First Medical Center of Chinese PLA General Hospital and Medical School of Chinese PLA, Haidian District, Beijing 100853, China., Beijing 100853, China. hehuixia@301hospital.com.cn |
| Key Words |
Hypobaric hypoxia exposure; Anxiety; Depression; Oral microbiota; Fecal microbiota; Lactobacillus |
| Core Tip |
The effects of hypobaric hypoxia (HH) exposure (HHE) on anxiety- and depression-like behaviors in mice were analyzed. HHE for one day activated several brain nuclei, including the anterior cingulate cortex, paraventricular thalamic nucleus, lateral habenula, paraventricular hypothalamic nucleus, lateral hypothalamus, and anterior periaqueductal gray. A significant decrease in Lactobacillus abundance was found in the oral microbiota following one day of HH. Both oral application and gavage administration of a Lactobacillus complex effectively alleviated anxiety- and depression-like behaviors in mice subjected to one day of HH. |
| Publish Date |
2025-05-29 09:14 |
| Citation |
<p>Chang WY, Qin QZ, Li XT, Wang JJ, Chen Y, Ruan HQ, Qu YN, Jiang XX, He HX. Modulating oral microbiota ameliorates hypobaric hypoxia-induced anxiety- and depression-like behaviors in mice. <i>World J Psychiatry</i> 2025; 15(6): 104809</p> |
| URL |
https://www.wjgnet.com/2220-3206/full/v15/i6/104809.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v15.i6.104809 |
