Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	104842
Country	China

Received	2025-01-06 05:01
Peer-Review Started	2025-01-06 05:01
To Make the First Decision
Return for Revision	2025-03-11 07:29
Revised	2025-03-20 01:49
Second Decision	2025-04-01 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-01 05:52
Articles in Press	2025-04-01 05:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-04-16 05:41
Publish the Manuscript Online	2025-05-15 10:28

ISSN	1948-5204 (online)
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Category	Oncology
Manuscript Type	Editorial
Article Title	Up-regulated programmed cell death protein-1/its ligand 1 expression promotes metabolic dysfunction-associated steatotic liver disease malignant progression
Manuscript Source	Invited Manuscript
All Author List	Min Xu, Tian-Tian Ruan, Hao Tang, Rong-Fei Fang, Wen-Li Sai, Qun Xie, Deng-Fu Yao and Min Yao
ORCID	Author(s) ORCID Number Min Xu http://orcid.org/0009-0006-5139-9914 Tian-Tian Ruan http://orcid.org/0009-0004-9895-0051 Hao Tang http://orcid.org/0000-0001-8518-4512 Rong-Fei Fang http://orcid.org/0000-0002-3255-5014 Wen-Li Sai http://orcid.org/0000-0002-9618-2720 Qun Xie http://orcid.org/0000-0002-4798-513X Deng-Fu Yao http://orcid.org/0000-0002-3448-7756 Min Yao http://orcid.org/0000-0002-5473-0186
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 81673241 National Natural Science Foundation of China No. 32470985
Corresponding Author	Deng-Fu Yao, Department of Immunology, Medical School of Nantong University and Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, No. 20 West Temple Road, Nantong 226001, Jiangsu Province, China. yaodf@ahnmc.com
Key Words	Hepatocytes; Metabolic dysfunction-associated steatotic/fatty liver disease; Programmed cell death protein-1; Programmed cell death protein ligand-1; Immune escape
Core Tip	Hepatocellular carcinoma (HCC) is associated with hepatitis virus (hepatitis B virus or hepatitis C virus) infection and increasing metabolic dysfunction-associated steatotic/fatty liver disease (MASLD/MAFLD). Virus vaccines and antiviral therapy are considered key prevention and anti-viral treatments for HCC. Recently, interesting observation was that MASLD malignant progression was associated with higher programmed cell death protein-1/its ligand 1 (PD-1/PD-L1) expression. Therefore, inhibiting PD-1/PD-L1 except of HCC therapy could be a promising target to prevent or delay the malignant transformation of hepatocytes.
Publish Date	2025-05-15 10:28
Citation	<p>Xu M, Ruan TT, Tang H, Fang RF, Sai WL, Xie Q, Yao DF, Yao M. Up-regulated programmed cell death protein-1/its ligand 1 expression promotes metabolic dysfunction-associated steatotic liver disease malignant progression. <i>World J Gastrointest Oncol</i> 2025; 17(5): 104842</p>
URL	https://www.wjgnet.com/1948-5204/full/v17/i5/104842.htm
DOI	https://dx.doi.org/10.4251/wjgo.v17.i5.104842

Full Article (PDF)	WJGO-17-104842-with-cover.pdf
Manuscript File	104842_Auto_Edited_004830.docx
Answering Reviewers	104842-answering-reviewers.pdf
Audio Core Tip	104842-audio.m4a
Conflict-of-Interest Disclosure Form	104842-conflict-of-interest-statement.pdf
Copyright License Agreement	104842-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	104842-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	104842-non-native-speakers.pdf
Peer-review Report	104842-peer-reviews.pdf
Scientific Misconduct Check	104842-scientific-misconduct-check.png
Scientific Editor Work List	104842-scientific-editor-work-list.pdf
CrossCheck Report	104842-crosscheck-report.pdf