Publication Name	World Journal of Gastroenterology
Manuscript ID	10488
Country	Poland

Received	2014-04-02 19:56
Peer-Review Started	2014-04-02 21:48
To Make the First Decision	2014-05-13 20:46
Return for Revision	2014-05-21 08:46
Revised	2014-06-03 00:00
Second Decision	2014-06-26 16:51
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-06-26 17:39
Articles in Press	2014-06-26 17:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-09-10 20:14
Publish the Manuscript Online	2014-10-01 20:25

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Case Control Study
Article Title	Decreased serum platelet derived growth factor BB levels in acute and increased in chronic pancreatitis
Manuscript Source	Unsolicited Manuscript
All Author List	Magdalena Stojek, Krystian Adrych, Lukasz Rojek, Marian Smoczynski, Tomasz Sledzinski, Sylwia Szrok and Julian Swierczynski
Funding Agency and Grant Number	Funding Agency Grant Number Medical University of Gdansk ST-43 Medical University of Gdansk ST-40 Medical University of Gdansk ST-41 Polpharma (Starogard Gdanski)
Corresponding Author	Julian Swierczynski, Professor, Department of Biochemistry, Medical University of Gdansk, ul. Debinki 1, 80-211 Gdansk, Poland. juls@gumed.edu.pl
Key Words	Acute pancreatitis; Chronic pancreatitis; Walled-off pancreatic necrosis; Growth factors; Platelet derived growth factor BB; Transforming growth factor -1; High-mobility group box chromosomal protein 1; Chemerin
Core Tip	Patients with mild acute pancreatitis (AP) and patients with walled-off pancreatic necrosis (WOPN) had significantly lower serum levels of platelet derived growth factor BB (PDGF-BB) compared to healthy subjects. In contrast, alcoholic chronic pancreatitis (CP) was associated with higher serum levels of PDGF-BB. Circulating transforming growth factor ?1 and chemerin levels were elevated in CP patients, but not in patients with AP and WOPN. No significant changes in serum high-mobility group box chromosomal protein 1 levels were found either in patients with AP, WOPN or CP. These data suggest that selected growth factors and cytokines may be considered as potential diagnostic biomarkers in patients with pancreatic diseases.
Publish Date	2014-10-01 20:25
Citation	Stojek M, Adrych K, Rojek L, Smoczynski M, Sledzinski T, Szrok S, Swierczynski J. Decreased serum platelet derived growth factor BB levels in acute and increased in chronic pancreatitis. World J Gastroenterol 2014; 20(36): 13127-13132
URL	http://www.wjgnet.com/1007-9327/full/v20/i36/13127.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i36.13127

Full Article (PDF)	WJG-20-13127.pdf
Full Article (Word)	WJG-20-13127.doc
Manuscript File	10488-Review.docx
Answering Reviewers	10488-Answering reviewers.pdf
Copyright License Agreement	10488-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20140402174157.pdf
Peer-review Report	10488-Peer reviews.pdf
Scientific Misconduct Check	10488-CrossCheck.jpg
Scientific Editor Work List	10488-Scientific editor work list.pdf