| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Anti-RPL30 as a novel biomarker for enhanced diagnosis of autoantibody-negative primary biliary cholangitis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhi-Yu Zeng, Zu-Xiong Huang, Yi-Ran Wang, Long-Ke Xie, Yi-Ping Lin, Ying Liang, Zi-Ying Liu, Dong-Liang Li and Xiao-Yong Zhang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82172257 |
| Health Care Major Project of Guangzhou |
202206080001 |
| Science and Technology Cooperation Program of Fujian Province |
2021I0036 |
|
| Corresponding Author |
Xiao-Yong Zhang, MD, PhD, State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Hepatology Unit and Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, 510515, China, Guangzhou 510515, Guangdong Province, China. xiaoyzhang@smu.edu.cn |
| Key Words |
Primary biliary cholangitis; Protein microarray assay; Ribosomal protein L30; Diagnosis; Autoantibody-negative |
| Core Tip |
The diagnosis of autoantibody-negative primary biliary cholangitis (PBC) remains challenging and is typically confirmed through liver needle biopsy. Using the immunome protein array, RPL30 was identified as a novel biomarker for PBC. Validation of the RPL30 autoantibody through enzyme-linked immunosorbent assay showed a higher positivity rate in autoantibody-negative PBC cases, including anti-mitochondrial antibody, anti-mitochondrial E2 subunit antibody, anti-glycoprotein 210, and anti-speckled protein 100-negative cases, compared to the healthy control group. Anti-RPL30 improved the diagnostic rate of antibody-negative PBC and correlated with hepatic damage, poorer synthetic function, and higher Model for End-Stage Liver Disease scores. |
| Publish Date |
2025-05-28 07:32 |
| Citation |
<p>Zeng ZY, Huang ZX, Wang YR, Xie LK, Lin YP, Liang Y, Liu ZY, Li DL, Zhang XY. Anti-RPL30 as a novel biomarker for enhanced diagnosis of autoantibody-negative primary biliary cholangitis. <i>World J Gastroenterol</i> 2025; 31(20): 104891</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i20/104891.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i20.104891 |
