| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Interventional effect of hesperetin on N-methyl-N’-nitro-N-nitrosoguanidine-induced exosomal circ008274 in affecting normal cells to promote gastric carcinogenesis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhao-Feng Liang, Yu-Meng Xu, Jia-Jia Song, Zi-Han Gao, Hui Qian and Xue-Zhong Xu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 81602883 |
| Technology Development Project of Jiangsu University |
No. 20220516 |
| Postgraduate Research and Practice Innovation Program of Jiangsu Province |
No. KYCX233765 |
|
| Corresponding Author |
Zhao-Feng Liang, Wujin Institute of Molecular Diagnostics and Precision Cancer Medicine of Jiangsu University, Wujin Hospital Affiliated with Jiangsu University, No. 2 Yongning North Road, Tianning District, Changzhou 213017, Jiangsu Province, China. liangzhaofeng@ujs.edu.cn |
| Key Words |
Hesperetin; Gastric cancer; N-methyl-N’-nitro-N-nitrosoguanidine; Exosomes; Circ0008274 |
| Core Tip |
Hesperetin, a citrus flavonoid, shows potential in inhibiting gastric cancer initiation and progression, but its mechanisms remain unclear. This study explored its role in countering N-methyl-N’-nitro-N-nitrosoguanidine-induced gastric carcinogenesis mediated by exosomal circular RNA. Bioinformatics and biological experiments revealed that exosomes from TGES-1 cells enhanced GES-1 cell proliferation, migration, invasion, epithelial-mesenchymal transition (EMT), and stemness, but hesperetin pretreatment significantly reduced these effects. Hesperetin targeted exosomal circ0008274, which interacts with miR-526b-5p, to inhibit cancer-promoting properties. Overexpression or knockdown of circ0008274 confirmed its role in promoting GES-1 cell proliferation, EMT, and stemness via miR-526b-5p. Hesperetin intervenes in gastric carcinogenesis by modulating the exosomal circ0008274/miR-526b-5p axis. |
| Publish Date |
2025-04-27 03:54 |
| Citation |
<p>Liang ZF, Xu YM, Song JJ, Gao ZH, Qian H, Xu XZ. Interventional effect of hesperetin on N-methyl-N’-nitro-N-nitrosoguanidine-induced exosomal circ008274 in affecting normal cells to promote gastric carcinogenesis. <i>World J Gastroenterol</i> 2025; 31(16): 104920</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i16/104920.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i16.104920 |
