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Articles Published Processes
3/25/2025 4:19:17 PM | Browse: 7 | Download: 30
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Received |
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2025-01-08 08:20 |
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Peer-Review Started |
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2025-01-08 08:20 |
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To Make the First Decision |
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Return for Revision |
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2025-01-18 10:03 |
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Revised |
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2025-01-26 09:21 |
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Second Decision |
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2025-02-21 02:38 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-02-21 07:23 |
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Articles in Press |
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2025-02-21 07:23 |
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Publication Fee Transferred |
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2025-02-06 14:34 |
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Edit the Manuscript by Language Editor |
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2025-02-23 15:02 |
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Typeset the Manuscript |
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2025-03-07 08:00 |
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Publish the Manuscript Online |
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2025-03-25 16:19 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Tetramethylpyrazine induces reactive oxygen species-based mitochondria-mediated apoptosis in colon cancer cells
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yan-Xu Hou, Wei Ren, Qing-Qiang He, Li-Yan Huang, Tian-Hua Gao and Hua Li |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Hua Li, Chief Physician, PhD, Department of Surgical Oncology, Xing Tai People Hospital of Hebei Medical University, No.818 Xiangdu North Street, Xingtai 054001, Hebei Province, China. 19131344440@163.com |
| Key Words |
Tetramethylpyrazine; Colon cancer; Reactive oxygen species; Apoptosis; Cell proliferation |
| Core Tip |
The incidence and mortality of colon cancer are increasing each year. Because of limited therapeutic treatments and low survival rate of advanced stage patients and the development of drug resistance, new treatments are urgently required. We found that tetramethylpyrazine (TMP) increases the generation of intracellular reactive oxygen species and triggers mitochondria-mediated apoptosis in a caspase-dependent manner. Our results suggest that TMP may be a potential therapeutic drug for the treatment of colon cancer. |
| Publish Date |
2025-03-25 16:19 |
| Citation |
<p>Hou YX, Ren W, He QQ, Huang LY, Gao TH, Li H. Tetramethylpyrazine induces reactive oxygen species-based mitochondria-mediated apoptosis in colon cancer cells. <i>World J Gastrointest Oncol</i> 2025; 17(4): 104922</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i4/104922.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i4.104922 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
