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Articles Published Processes
5/30/2025 10:57:33 AM | Browse: 18 | Download: 16
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Received |
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2025-02-12 08:20 |
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Peer-Review Started |
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2025-02-12 08:21 |
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To Make the First Decision |
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Return for Revision |
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2025-03-06 07:10 |
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Revised |
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2025-03-13 13:59 |
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Second Decision |
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2025-05-06 02:57 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-05-06 07:39 |
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Articles in Press |
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2025-05-06 07:39 |
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Publication Fee Transferred |
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2025-03-14 12:41 |
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Edit the Manuscript by Language Editor |
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2025-05-14 00:06 |
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Typeset the Manuscript |
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2025-05-23 07:06 |
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Publish the Manuscript Online |
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2025-05-30 10:57 |
| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medical Laboratory Technology |
| Manuscript Type |
Observational Study |
| Article Title |
Clinical significance of immune cell and biomarker changes in liver cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Su-Tao Zhou, Bin Zhang, Ke Ma and Juan Guo |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Su-Tao Zhou, Department of Laboratory Medicine, The First Affiliated Hospital of Hebei North University, No. 12 Changqing Road, Zhangjiakou 075000, Hebei Province, China. zjkzhousutao@163.com |
| Key Words |
Primary liver cancer; CD3; CD8; CD56; CD161; Natural killer T cell; Alpha fetoprotein; Glutamyl transpeptidase |
| Core Tip |
This investigation garnered peripheral blood samples from 30 primary liver cancer (PLC) patients and 30 healthy individuals to determine CD4+, CD8+, CD3+CD56+, CD8+CD56+, CD3+CD161+, and CD3-CD161+ natural killer (NK) T cell levels, as well as alpha fetoprotein (AFP) and glutamyl transpeptidase (GGT) contents. The aim is to confirm the diagnostic value of NKT cell subsets, AFP, and GGT levels in the context of PLC. The outcomes revealed a marked increase in the levels of CD8+CD56+NKT, CD3+CD161+NKT, CD3-CD161+NKT, AFP, and GGT in PLC patients’ peripheral blood. Combining these five indicators for detection enhanced the sensitivity and specificity of PLC diagnosis. Our findings demonstrated that placing emphasis on the combined detection of CD8+CD56+NKT, CD3+CD161+NKT, and CD3-CD161+NKT cells may play an essential part in improving the early diagnosis of PLC in clinical practice. |
| Publish Date |
2025-05-30 10:57 |
| Citation |
<p>Zhou ST, Zhang B, Ma K, Guo J. Clinical significance of immune cell and biomarker changes in liver cancer. <i>World J Gastrointest Surg</i> 2025; 17(6): 104923</p> |
| URL |
https://www.wjgnet.com/1948-9366/full/v17/i6/104923.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v17.i6.104923 |
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