Publication Name	World Journal of Transplantation
Manuscript ID	104945
Country	Bulgaria

Received	2025-01-07 07:20
Peer-Review Started	2025-01-07 07:21
To Make the First Decision
Return for Revision	2025-02-18 10:19
Revised	2025-03-03 15:30
Second Decision	2025-04-14 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-14 09:33
Articles in Press	2025-04-14 09:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-10-22 00:34
Publish the Manuscript Online	2025-11-19 05:57

ISSN	2220-3230 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Field of Vision
Article Title	Current perspectives and guidelines on liver transplantation for metastatic colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Mirela Stoyanova, Irena Mircheva, Ivan Chulkov, Madlena Karamiteva, Zvezdina Goranova, Viktoria Simeonova, Miroslav Zashev, Tsvetelina Velikova and Milena Peruhova
ORCID	Author(s) ORCID Number Mirela Stoyanova http://orcid.org/0009-0000-6052-7152 Irena Mircheva http://orcid.org/0009-0000-4160-9929 Ivan Chulkov http://orcid.org/0009-0006-6276-7276 Madlena Karamiteva http://orcid.org/0009-0009-5501-2889 Viktoria Simeonova http://orcid.org/0009-0004-6981-9556 Miroslav Zashev http://orcid.org/0000-0003-3265-1548
Funding Agency and Grant Number	Funding Agency Grant Number the European Union-NextGenerationEU, through the National Recovery and Resilience Plan of the Republic of Bulgaria BG-RRP-2.004-0008
Corresponding Author	Miroslav Zashev, Assistant Professor, Chief Physician, MD, Department of General Surgery, Heart and Brain Hospital, Zdrave 1 Str, Burgas 8000, Bulgaria. zashev.md@gmail.com
Key Words	Liver transplantation; Colorectal cancer; Colorectal liver metastasis; Transplant oncology
Core Tip	It is a well-established fact that more than 40% of patients with colorectal cancer (CRC) develop liver metastasis during the disease course despite all the surveys leading to more suitable systemic treatments, efficient chemotherapy, and surgical resections. liver transplantation (LT) could be a treatment option for patients with unresectable CRC liver metastasis without extrahepatic involvement. The initial assessment and proper selection of suitable patients is mandatory for better outcomes for these patients. It turns out that to be candidates for an LT, patients have to meet strict criteria described in the two prospective studies, SECA-I and SECA-II. Despite the proven benefits of LT for non-resectable colorectal liver metastases, this method is still not widely used worldwide due to a lack of policy and healthcare reforms in many countries.
Publish Date	2025-11-19 05:57
Citation	<p>Stoyanova M, Mircheva I, Chulkov I, Karamiteva M, Goranova Z, Simeonova V, Zashev M, Velikova T, Peruhova M. Current perspectives and guidelines on liver transplantation for metastatic colorectal cancer. <i>World J Transplant</i> 2025; 15(4): 104945</p>
URL	https://www.wjgnet.com/2220-3230/full/v15/i4/104945.htm
DOI	https://dx.doi.org/10.5500/wjt.v15.i4.104945

Full Article (PDF)	WJT-15-104945-with-cover.pdf
Manuscript File	104945_Auto_Edited_040914.docx
Answering Reviewers	104945-answering-reviewers.pdf
Audio Core Tip	104945-audio.mp3
Conflict-of-Interest Disclosure Form	104945-conflict-of-interest-statement.pdf
Copyright License Agreement	104945-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	104945-non-native-speakers.pdf
Peer-review Report	104945-peer-reviews.pdf
Scientific Editor Work List	104945-scientific-editor-work-list.pdf
CrossCheck Report	104945-crosscheck-report.pdf