BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
6/13/2025 11:47:48 AM | Browse: 18 | Download: 243
 |
Received |
|
2025-01-10 10:29 |
|
Peer-Review Started |
|
2025-01-13 00:57 |
 |
To Make the First Decision |
|
|
|
Return for Revision |
|
2025-02-11 07:41 |
|
Revised |
|
2025-02-19 11:56 |
|
Second Decision |
|
2025-03-17 07:06 |
|
Accepted by Journal Editor-in-Chief |
|
|
|
Accepted by Executive Editor-in-Chief |
|
2025-04-03 07:25 |
|
Articles in Press |
|
2025-04-03 07:25 |
|
Publication Fee Transferred |
|
2025-02-26 05:20 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2025-05-27 02:50 |
|
Publish the Manuscript Online |
|
2025-06-13 11:47 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Ras homolog enriched in brain 1 regulates β cell mass and β cell function via mTORC1/AMPK/Notch1 pathways
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yan Yang, Wan-Juan Song and Jing-Jing zhang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82430029 |
| National Natural Science Foundation of China |
82330025 |
| National Natural Science Foundation of China |
82370807 |
| National Natural Science Foundation of China |
82070807 |
| Leading Talents Program of Hunan Province |
2022RC3078 |
| Natural Science Foundation of Hunan Province, China |
2021JJ30976 |
|
| Corresponding Author |
Jing-Jing zhang, MD, PhD, National Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology, Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Renmin middle road, Changsha 410011, Hunan Province, China. doctorzhangjj@csu.edu.cn |
| Key Words |
Rheb1; β cells; Diabetes; mTOR; AMP-activated protein kinase; Hepatocyte nuclear factor4-alpha |
| Core Tip |
Mechanisms underlying β cell dysfunction in diabetes remains unclear, our study explores the role of Ras homolog enriched in brain 1 (Rheb1) in regulating β-cell function and proliferation. The researchers found that Rheb1 is more highly expressed in islets from younger individuals (under 18) compared to adults. Rheb1 promotes β-cell proliferation through both the mTORC1 and AMP-activated protein kinase pathways, rather than relying solely on mTORC1. Moreover, Rheb1 also upregulated key transcription factor HNF4α in β cells. These findings suggest that Rheb1 plays a vital role in β-cell growth and function, making it a promising target for diabetes therapy. |
| Publish Date |
2025-06-13 11:47 |
| Citation |
<p>Yang Y, Song WJ, zhang JJ. Ras homolog enriched in brain 1 regulates β cell mass and β cell function via mTORC1/AMPK/Notch1 pathways. <i>World J Diabetes</i> 2025; 16(6): 104973</p> |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i6/104973.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i6.104973 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
