Publication Name	World Journal of Psychiatry
Manuscript ID	104995
Country	China

Received	2025-01-10 08:51
Peer-Review Started	2025-01-10 08:52
To Make the First Decision
Return for Revision	2025-02-13 08:05
Revised	2025-02-19 01:57
Second Decision	2025-04-07 10:39
Accepted by Journal Editor-in-Chief	2025-04-07 14:42
Accepted by Executive Editor-in-Chief	2025-04-08 08:25
Articles in Press	2025-04-08 08:25
Publication Fee Transferred	2025-02-20 18:46
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-04-21 01:47
Publish the Manuscript Online	2025-04-30 08:58

ISSN	2220-3206 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Psychiatry
Manuscript Type	Observational Study
Article Title	Factors influencing anxiety and depression in advanced hepatocellular carcinoma patients and their impact on quality of life
Manuscript Source	Unsolicited Manuscript
All Author List	Maher Hendi, Bin Zhang, Jie-Min Lv and Xiu-Jun Cai
ORCID	Author(s) ORCID Number Xiu-Jun Cai http://orcid.org/0000-0002-8178-0760
Funding Agency and Grant Number
Corresponding Author	Xiu-Jun Cai, FACS, FRCS, MD, PhD, Professor, Department of General Surgery, Zhejiang University School of Medicine, Sir Run Run Shaw Hospital, No. 3 East Qingchun Road, Hangzhou 310016, Zhejiang Province, China. srrs_cxj@163.com
Key Words	Advanced hepatocellular carcinoma; Anxiety; Depression; Quality of life; Influencing factors
Core Tip	Patients middle and advanced hepatocellular carcinoma (HCC) often experience significant anxiety and depression, which may severely affect their quality of life. This study assessed the anxiety and depression status of patients middle and advanced HCC and their influencing factors, analyzing the correlation between these psychological factors and quality of life. According to the results, a large number of advanced HCC patients suffer from depression and anxiety, which are negatively associated with social support and a high quality of life. Hamilton Anxiety Rating Scale and Hamilton Depression Rating Scale scores, prior liver resection, Barcelona Clinic Liver Cancer C stage, and multiple tumors are risk factors for depression in advanced HCC patients. Meanwhile, Karnofsky performance scores are negatively correlated with anxiety, and independent risk factors for anxiety include age over 60, a history of alcohol consumption, Hamilton Anxiety Rating Scale and Hamilton Depression Rating Scale scores, prior liver resection, Barcelona Clinic Liver Cancer C stage, and multiple tumors. Anxiety and depression scores in liver cancer patients are negatively correlated with quality of life.
Publish Date	2025-04-30 08:58
Citation	<p>Hendi M, Zhang B, Lv JM, Cai XJ. Factors influencing anxiety and depression in advanced hepatocellular carcinoma patients and their impact on quality of life. <i>World J Psychiatry</i> 2025; 15(5): 104995</p>
URL	https://www.wjgnet.com/2220-3206/full/v15/i5/104995.htm
DOI	https://dx.doi.org/10.5498/wjp.v15.i5.104995

Full Article (PDF)	WJP-15-104995-with-cover.pdf
STROBE Statement	104995-STROBE-statement.pdf
Manuscript File	104995_Auto_Edited_013730.docx
Answering Reviewers	104995-answering-reviewers.pdf
Audio Core Tip	104995-audio.m4a
Biostatistics Review Certificate	104995-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	104995-conflict-of-interest-statement.pdf
Copyright License Agreement	104995-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s)	104995-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	104995-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	104995-non-native-speakers.pdf
Supplementary Material	104995-supplementary-material.pdf
Peer-review Report	104995-peer-reviews.pdf
Journal Editor-in-Chief Review Report	104995-journal-editor-in-chief.pdf
Scientific Misconduct Check	104995-scientific-misconduct-check.png
Scientific Editor Work List	104995-scientific-editor-work-list.pdf
CrossCheck Report	104995-crosscheck-report.pdf