| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Multi-omics reveals the associations among the fecal metabolome, intestinal bacteria, and serum indicators in patients with hepatocellular carcinoma
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jing Feng, Jun-Ping Wang, Jian-Ran Hu, Ping Li, Pin Lv, Hu-Cheng He, Xiao-Wei Cheng, Zheng Cao, Jia-Jing Han, Qiang Wang, Qian Su and Li-Xin Liu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Department of Science and Technology of Shanxi Province |
No. 20210302124369 |
| Health Commission of Shanxi Province |
No. 2021116 |
| Shanxi Administration of Traditional Chinese Medicine |
No. 2024ZYY2C054 |
|
| Corresponding Author |
Li-Xin Liu, Department of Gastroenterology, The First Hospital of Shanxi Medical University, No. 85 Jiefang South Road, Yingze District, Taiyuan 030001, Shanxi Province, China. lixinliu6@hotmail.com |
| Key Words |
Hepatocellular carcinoma; Fecal metabolomics; Intestinal bacteria; Correlation analysis; Non-targeted liquid chromatography-mass spectrometry |
| Core Tip |
This study investigated the alterations in the fecal metabolome and intestinal bacteria, and elucidated the correlations among differential metabolites, distinct bacterial taxa, and serum indicators. By employing non-targeted liquid chromatography-mass spectrometry and high-throughput DNA sequencing technologies, the researchers discovered that three Kyoto Encyclopedia of Genes and Genomes pathways, namely retinol metabolism, steroid hormone biosynthesis, and ascorbate and aldarate metabolism, were significantly enriched by differential metabolites, along with three representative bacterial genera: Streptococcus, Veillonella, and Lachnospira. Notably, Streptococcus and Veillonella exhibited evident correlations with serum indicators and differential metabolites. The findings suggest that the fecal metabolome and the composition of intestinal bacteria hold considerable potential as biomarkers for the diagnosis of hepatocellular carcinoma. |
| Publish Date |
2025-04-18 07:43 |
| Citation |
<p>Feng J, Wang JP, Hu JR, Li P, Lv P, He HC, Cheng XW, Cao Z, Han JJ, Wang Q, Su Q, Liu LX. Multi-omics reveals the associations among the fecal metabolome, intestinal bacteria, and serum indicators in patients with hepatocellular carcinoma. <i>World J Gastroenterol</i> 2025; 31(15): 104996</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i15/104996.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i15.104996 |
