4/11/2025 2:19:31 AM | Browse: 29 | Download: 66
| Publication Name | World Journal of Gastroenterology |
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| Manuscript ID | 105004 |
| Country | China |
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| ISSN | 1007-9327 (print) and 2219-2840 (online) |
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| Open Access | This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright | © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247 |
| Permissions | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207 |
| Publisher | Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website | http://www.wjgnet.com |
| Category | Gastroenterology & Hepatology | ||||||||||||||||||||
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| Manuscript Type | Clinical Trials Study | ||||||||||||||||||||
| Article Title | Efficacy of recombinant human thrombopoietin in patients with acute-on-chronic liver failure and thrombocytopenia: A prospective, open-label study | ||||||||||||||||||||
| Manuscript Source | Unsolicited Manuscript | ||||||||||||||||||||
| All Author List | Gang Liu, Fei Tang, Tao Wang, Jun-Qing Yan, Feng-Hui Li, Fu-Shuang Ha, Xu Zhang, Li Jing and Jing Liang | ||||||||||||||||||||
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| Corresponding Author | Jing Liang, Chief Physician, MD, Department of Gastroenterology and Hepatology, The Third Central Hospital of Tianjin, No. 83 Jintang Road, Tianjin 300170, China. haolele77@sina.com | ||||||||||||||||||||
| Key Words | Recombinant human thrombopoietin; Acute-on-chronic liver failure; Thrombocytopenia; Hepatocyte growth factor; Prognosis | ||||||||||||||||||||
| Core Tip | Patients with acute-on-chronic liver failure (ACLF) have a high mortality rate and poor prognosis. They often experience concurrent thrombocytopenia and bleeding events. This study aimed to evaluate the efficacy and safety of recombinant human thrombopoietin (rhTPO) in ACLF patients with concomitant severe thrombocytopenia. We assigned 70 ACLF patients with severe thrombocytopenia into the rhTPO group and the control group, with 35 patients in each group. Patients in the rhTPO group received subcutaneous injections of rhTPO for 7 consecutive days, while those in the control group did not receive rhTPO treatment. The platelet count in the rhTPO group increased significantly from the baseline. The model for end-stage liver disease score, albumin level, and international normalized ratio in patients of the rhTPO group improved significantly from the baseline on day 14 after rhTPO injection. In summary, rhTPO can significantly increase the platelet count in ACLF patients with thrombocytopenia, help improve liver function, and reduce the occurrence of bleeding events. It also has a good safety profile. | ||||||||||||||||||||
| Publish Date | 2025-04-11 02:19 | ||||||||||||||||||||
| Citation | <p>Liu G, Tang F, Wang T, Yan JQ, Li FH, Ha FS, Zhang X, Jing L, Liang J. Efficacy of recombinant human thrombopoietin in patients with acute-on-chronic liver failure and thrombocytopenia: A prospective, open-label study. <i>World J Gastroenterol</i> 2025; 31(14): 105004</p> | ||||||||||||||||||||
| URL | https://www.wjgnet.com/1007-9327/full/v31/i14/105004.htm | ||||||||||||||||||||
| DOI | https://dx.doi.org/10.3748/wjg.v31.i14.105004 |
| Full Article (PDF) | WJG-31-105004-with-cover.pdf |
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| CONSORT 2010 Statement | 105004-CONSORT-2010-statement.pdf |
| Manuscript File | 105004_Auto_Edited_075908.docx |
| Answering Reviewers | 105004-answering-reviewers.pdf |
| Audio Core Tip | 105004-audio.m4a |
| Biostatistics Review Certificate | 105004-biostatistics-statement.pdf |
| Clinical Trial Registration Statement | 105004-clinical-trial-registration-statement.pdf |
| Conflict-of-Interest Disclosure Form | 105004-conflict-of-interest-statement.pdf |
| Copyright License Agreement | 105004-copyright-assignment.pdf |
| Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) | 105004-foundation-statement.pdf |
| Signed Informed Consent Form(s) or Document(s) | 105004-informed-consent-statement.pdf |
| Institutional Review Board Approval Form or Document | 105004-institutional-review-board-statement.pdf |
| Non-Native Speakers of English Editing Certificate | 105004-non-native-speakers.pdf |
| Peer-review Report | 105004-peer-reviews.pdf |
| Scientific Misconduct Check | 105004-scientific-misconduct-check.png |
| Scientific Editor Work List | 105004-scientific-editor-work-list.pdf |
| CrossCheck Report | 105004-crosscheck-report.pdf |