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Articles Published Processes
6/4/2025 7:41:50 AM | Browse: 3 | Download: 15
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Received |
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2025-01-13 10:12 |
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Peer-Review Started |
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2025-01-13 10:12 |
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To Make the First Decision |
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Return for Revision |
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2025-03-12 06:51 |
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Revised |
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2025-03-24 15:22 |
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Second Decision |
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2025-05-06 02:51 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-05-07 10:01 |
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Articles in Press |
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2025-05-07 10:01 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-05-26 02:17 |
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Publish the Manuscript Online |
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2025-06-04 07:41 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Exploring macrophage polarization as a prognostic indicator for colorectal cancer: Unveiling the impact of metalloproteinase mutations
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Eduardo Brambilla, Daniel Jun Funatsu Brambilla, Aline Caldart Tregnago, Floriano Riva, Fabio Firmbach Pasqualotto and Jonathan Soldera |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Jonathan Soldera, PhD, Professor, Gastroenterology, University of South Wales, University of South Wales, Cardiff CF37 1DL, United Kingdom, Cardiff CF37 1DL, United Kingdom. jonathansoldera@gmail.com |
| Key Words |
Colorectal neoplasia; Polarized macrophages; Colorectal adenocarcinoma; Microsatellite instability |
| Core Tip |
This study investigates the prognostic significance of macrophage polarization in colorectal cancer (CRC), focusing on patients with and without metalloproteinase mutations. Using M1 (inducible nitric oxide synthase) and M2 (CD163, CD206) markers, macrophage densities were quantified and correlated with survival and clinical outcomes. While no significant differences in macrophage density or polarization were observed between groups, the study highlights a potential protective role of metalloproteinase mutations, as patients harboring these mutations demonstrated improved survival rates. This insight may guide future research into the tumor microenvironment and its implications for CRC prognosis and therapy. |
| Publish Date |
2025-06-04 07:41 |
| Citation |
<p>Brambilla E, Brambilla DJF, Tregnago AC, Riva F, Pasqualotto FF, Soldera J. Exploring macrophage polarization as a prognostic indicator for colorectal cancer: Unveiling the impact of metalloproteinase mutations. <i>World J Clin Cases</i> 2025; 13(23): 105011</p> |
| URL |
https://www.wjgnet.com/2307-8960/full/v13/i23/105011.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v13.i23.105011 |
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