| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Review |
| Article Title |
ATP-induced cell death in heart failure: Is there a link?
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jing-Jing Zhang, Lu Cheng, Qian Qiao, Xue-Liang Xiao, Shao-Jun Lin, Yue-Fang He, Ren-Luo Sha, Jun Sha, Yin Ma, Hao-Ling Zhang and Xue-Rui Ye |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science and Technology Department of Yunnan Province - Kunming Medical University, Kunming Medical Joint Special Project - Surface Project |
202401AY070001-164 |
| Yunnan Provincial Clinical Research Center Cardiovascular Diseases - New Technology Research for Development Project for Diagnosis and Treatment Cardiovascular Diseases |
202102AA310002 |
| the Key Technology Research and Device Development Project for Innovative Diagnosis and Treatment of Structural Heart Disease in the Southwest Plateau Region |
202302AA310045 |
|
| Corresponding Author |
Hao-Ling Zhang, PhD, Department of Biomedical Science, Advanced Medical and Dental Institute, University Sains Malaysia, 11800 Gelugor, Pulau Pinang, Penang 13200, Malaysia. zhaohaoling@student.usm.my |
| Key Words |
Heart failure; Adenosine triphosphate-induced cell death; Cardiomyopathy; Myocardial ischemia-reperfusion injury; Ejection fraction retention; Non-myocardial |
| Core Tip |
Heart failure (HF) has become a significant global health threat due to its complex pathophysiology and multifactorial causes. ATP-induced cell death (AICD) is a newly recognized form of regulated cell death, distinct from apoptosis and necrosis, characterized by energy depletion and metabolic disturbances resulting from excessive ATP accumulation. Recent studies indicate that AICD is primarily regulated by biological processes involving energy metabolism, redox balance, and intracellular calcium regulation. AICD plays a crucial role in heart failure, especially in conditions like myocardial infarction, ischemia-reperfusion injury, and chemotherapy. Investigating its role in heart failure pathogenesis could provide insights into new therapeutic strategies. This review summarizes recent findings on the link between AICD and heart failure, highlighting its impact on cardiac remodeling and disease progression. |
| Publish Date |
2025-04-21 08:12 |
| Citation |
<p>Zhang JJ, Cheng L, Qiao Q, Xiao XL, Lin SJ, He YF, Sha RL, Sha J, Ma Y, Zhang HL, Ye XR. ATP-induced cell death in heart failure: Is there a link? <i>World J Cardiol</i> 2025; 17(4): 105021</p> |
| URL |
https://www.wjgnet.com/1949-8462/full/v17/i4/105021.htm |
| DOI |
https://dx.doi.org/10.4330/wjc.v17.i4.105021 |
