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Articles Published Processes
7/14/2025 12:55:51 PM | Browse: 8 | Download: 30
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Received |
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2025-01-10 09:29 |
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Peer-Review Started |
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2025-01-10 09:29 |
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To Make the First Decision |
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Return for Revision |
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2025-02-14 01:52 |
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Revised |
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2025-02-19 03:03 |
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Second Decision |
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2025-02-26 02:39 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-02-26 06:36 |
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Articles in Press |
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2025-02-26 06:36 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-06-27 07:15 |
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Publish the Manuscript Online |
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2025-07-14 12:55 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Resveratrol: A promising agent in targeting senescent cancer-associated fibroblasts to inhibit pancreatic cancer progression
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hao Qin |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82304151 |
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| Corresponding Author |
Hao Qin, PhD, State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China. haoqin@bjmu.edu.cn |
| Key Words |
Pancreatic cancer; Cancer-associated fibroblasts; Resveratrol; Tumor microenvironment; Senescence-associated secretory phenotype |
| Core Tip |
ancreatic cancer remains a challenging disease with limited treatment options, largely due to the tumor microenvironment (TME) and its cancer-associated fibroblasts (CAFs). Senescent CAFs, through their senescence-associated secretory phenotype (SASP), contribute to tumor progression. Recent studies have explored the potential of resveratrol, a natural polyphenolic compound, to target these senescent CAFs. Resveratrol reduces the number of senescent CAFs, downregulates SASP factors, and disrupts tumor-promoting interactions in the TME. These findings suggest that resveratrol could serve as an effective adjunctive therapy for pancreatic cancer by modulating the TME and inhibiting cancer cell proliferation and metastasis. |
| Publish Date |
2025-07-14 12:55 |
| Citation |
<p>Qin H. Resveratrol: A promising agent in targeting senescent cancer-associated fibroblasts to inhibit pancreatic cancer progression. <i>World J Gastrointest Oncol</i> 2025; 17(7): 105034</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i7/105034.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i7.105034 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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