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5/27/2025 7:04:45 AM | Browse: 1 | Download: 6
Publication Name World Journal of Hepatology
Manuscript ID 105072
Country Mexico
Received
2025-01-11 13:41
Peer-Review Started
2025-01-21 09:21
To Make the First Decision
Return for Revision
2025-02-19 07:10
Revised
2025-02-27 16:15
Second Decision
2025-03-24 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2025-03-24 08:59
Articles in Press
2025-03-24 08:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-05-14 08:25
Publish the Manuscript Online
2025-05-27 07:04
ISSN 1948-5182 (online)
Open Access Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Letter to the Editor
Article Title Open questions on how metabolic dysfunction-associated steatotic liver disease shapes the course of drug-induced liver injury
Manuscript Source Invited Manuscript
All Author List Mariana M Ramírez-Mejía, Rolf Teschke and Nahum Méndez-Sánchez
ORCID
Author(s) ORCID Number
Mariana M Ramírez-Mejía http://orcid.org/0009-0005-6279-1527
Rolf Teschke http://orcid.org/0000-0001-8910-1200
Nahum Méndez-Sánchez http://orcid.org/0000-0001-5257-8048
Funding Agency and Grant Number
Corresponding Author Nahum Méndez-Sánchez, MD, PhD, Professor, Liver Research Unit, Medica Sur Clinic & Foundation, 150 Puente de Piedra, Mexico City 14050, Mexico. nmendez@medicasur.org.mx
Key Words Metabolic dysfunction-associated steatotic liver disease; Drug-induced liver injury; Metabolic dysfunction; Hepatotoxicity; Roussel Uclaf Causality Assessment Method; Immune response
Core Tip This article reviews the study by Zhao et al on the interaction between metabolic dysfunction-associated steatotic liver disease and drug-induced liver injury. This study highlights distinct clinical patterns in patients with metabolic dysfunction-associated steatotic liver disease and drug-induced liver injury, such as metabolic dysregulation (elevated triglycerides, cholesterol and insulin) and immune activation (increased levels of interleukin-4 and complement C3). The use of the updated Roussel Uclaf Causality Assessment Method strengthens the assessment of causality, emphasizing the need for tailored diagnostic approaches and therapeutic strategies. This work paves the way for prospective studies and biomarker discovery to improve patient outcomes at the intersection of these conditions.
Publish Date 2025-05-27 07:04
Citation <p>Ramírez-Mejía MM, Teschke R, Méndez-Sánchez N. Open questions on how metabolic dysfunction-associated steatotic liver disease shapes the course of drug-induced liver injury. <i>World J Hepatol</i> 2025; 17(5): 105072</p>
URL https://www.wjgnet.com/1948-5182/full/v17/i5/105072.htm
DOI https://dx.doi.org/10.4254/wjh.v17.i5.105072
Full Article (PDF) WJH-17-105072-with-cover.pdf
Manuscript File 105072_Auto_Edited_062116.docx
Answering Reviewers 105072-answering-reviewers.pdf
Audio Core Tip 105072-audio.m4a
Conflict-of-Interest Disclosure Form 105072-conflict-of-interest-statement.pdf
Copyright License Agreement 105072-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 105072-non-native-speakers.pdf
Peer-review Report 105072-peer-reviews.pdf
Scientific Misconduct Check 105072-scientific-misconduct-check.png
Scientific Editor Work List 105072-scientific-editor-work-list.pdf
CrossCheck Report 105072-crosscheck-report.pdf