Publication Name	World Journal of Biological Chemistry
Manuscript ID	10509
Country	India

Received	2014-04-03 20:56
Peer-Review Started	2014-04-04 07:47
To Make the First Decision	2014-04-28 14:30
Return for Revision	2014-04-30 19:44
Revised	2014-05-07 16:51
Second Decision	2014-06-11 14:12
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-06-11 14:31
Articles in Press	2014-06-11 15:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-08-29 15:17
Publish the Manuscript Online	2014-09-11 10:03

ISSN	1949-8454 (online)
Open Access
Copyright
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Matrix metalloproteinases and gastrointestinal cancers: Impacts of dietary antioxidants
Manuscript Source	Invited Manuscript
All Author List	Sugreev Verma, Kousik Kesh, Nilanjan Ganguly, Sayantan Jana and Snehasikta Swarnakar
Funding Agency and Grant Number	Funding Agency Grant Number Council of Scientific and Industrial Research, India (CSIR)-INDEPTH HUM projects
Corresponding Author	Dr. Snehasikta Swarnakar, CSIR-Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Jadavpur, Kolkata, India-700032, Phone: 91-332499-5824 Fax: 91-33-2473-5197, Email: snehasiktas@hotmail.com
Key Words	Gastrointestinal cancer; Matrix metalloproteinase; Reactive oxygen species; Antioxidants
Core Tip	Matrix metalloproteinases (MMPs) , a group of zinc dependent endopeptidases, substantially contribute to extra cellular remodelling, angiogenesis, cellular differentiation, proliferation and apoptosis. MMPs are also important regulators of tumor growth both at the primary site and in distant metastases; thus the enzymes are considered as important targets for cancer therapy. This review describes the roles and regulation of different MMPs and their subsequent actions over different gastrointestinal cancers both in epigenetic and cellular level. Furthermore, this review summarizes the current state of knowledge of dietary antioxidants in preventing gastrointestinal cancer progression as well as mechanism of action.
Publish Date	2014-09-11 10:03
Citation	Verma S, Kesh K, Ganguly N, Jana S, Swarnakar S. Matrix metalloproteinases and gastrointestinal cancers: Impacts of dietary antioxidants. World J Biol Chem 2014; 5(3): 355-376
URL	http://www.wjgnet.com/1949-8454/full/v5/i3/355.htm
DOI	http://dx.doi.org/10.4331/wjbc.v5.i3.355

Full Article (PDF)	WJBC-5-355.pdf
Full Article (Word)	WJBC-5-355.doc
Manuscript File	10509-Review.doc
Answering Reviewers	10509-Answering reviewers.pdf
Copyright License Agreement	10509-Copyright assignment.pdf
Peer-review Report	10509-Peer review(s).pdf
Scientific Misconduct Check	10509-CrossCheck.jpg
Scientific Editor Work List	10509-Scientific editor work list.pdf