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Articles Published Processes
10/24/2025 6:10:09 AM | Browse: 1 | Download: 0
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Received |
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2025-01-13 09:45 |
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Peer-Review Started |
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2025-01-13 09:45 |
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To Make the First Decision |
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Return for Revision |
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2025-05-12 10:00 |
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Revised |
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2025-05-26 13:54 |
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Second Decision |
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2025-09-03 02:50 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-09-03 10:04 |
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Articles in Press |
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2025-09-03 10:04 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-10-17 01:57 |
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Publish the Manuscript Online |
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2025-10-24 06:10 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Review |
| Article Title |
Oncogenic B-Raf proto-oncogene, serine/threonine kinase-mediated hedgehog signalling in the pathogenesis and targeted therapy of melanoma
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Rafiq A Rather |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science and Engineering Research Board |
No. PDF/2016/002730 |
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| Corresponding Author |
Rafiq A Rather, Assistant Professor, PhD, Department of Clinical Biochemistry, Govt. Degree College Shopian, Gagren, Shopian 192303, Jammu and Kashmir, India. rafiqahmad11@gmail.com |
| Key Words |
Melanoma; Hedgehog signaling; Acetylation; Mutations; Stem cells; Glioma-associated oncogene homolog; Targeted therapy |
| Core Tip |
Oncogenic B-Raf proto-oncogene, serine/threonine kinase activates the hedgehog signaling pathway, triggering glioma-associated oncogene homolog (GLI) 1/2 transcription factors that promote melanoma cell invasion and sustain cancer stem cell self-renewal, contributing to the malignancy’s therapeutic resistance. Histone deacetylases 1/2 (HDAC1/2) suppress the acetylation of GLI1/2, facilitating their activation. Inhibiting HDAC1/2 may stabilize GLI proteins in their inactive, acetylated form, offering a novel approach to inhibit melanoma progression. Hedgehog signaling induces HDAC1/2 expression, creating a feedback loop that amplifies GLI-mediated transcription, promoting cancer stem cell renewal. Disrupting this loop could unveil new therapeutic avenues for overcoming melanoma’s resistance to treatment. |
| Publish Date |
2025-10-24 06:10 |
| Citation |
<p>Rather RA. Oncogenic B-Raf proto-oncogene, serine/threonine kinase-mediated hedgehog signalling in the pathogenesis and targeted therapy of melanoma. <i>World J Clin Oncol</i> 2025; 16(10): 105117</p> |
| URL |
https://www.wjgnet.com/2218-4333/full/v16/i10/105117.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v16.i10.105117 |
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