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Articles Published Processes
6/12/2025 3:45:50 AM | Browse: 98 | Download: 564
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Received |
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2025-01-14 02:22 |
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Peer-Review Started |
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2025-01-14 02:22 |
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First Decision by Editorial Office Director |
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2025-03-21 22:59 |
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Return for Revision |
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2025-03-21 22:59 |
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Revised |
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2025-04-20 06:04 |
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Publication Fee Transferred |
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2025-04-23 03:35 |
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Second Decision by Editor |
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2025-05-26 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-05-26 07:29 |
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Articles in Press |
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2025-05-26 07:29 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-06-08 05:32 |
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Publish the Manuscript Online |
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2025-06-12 03:45 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
N6-methyladenosine reader IGF2BP2 regulates NIPSNAP1-mediated mitophagy and mitochondrial dynamics to alleviate hepatic ischemia-reperfusion injury
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shan-Shan Guo, Yan Zhao, Yan Hu, Xin-Ying Wang, Xu-Zi Zhao, Pei-Yan Zhong, Qin-Rong Luan, Zhe-Cheng Wang and Ji-Hong Yao |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82200658 |
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| Corresponding Author |
Zhe-Cheng Wang, PhD, Department of Pharmacology, Dalian Medical University, No. 9 West Section, Shunnan Road, Shunkou District, Dalian 116044, Liaoning Province, China. wangzc03@dmu.edu.cn |
| Key Words |
Hepatic ischemia-reperfusion; 4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1; Mitophagy; Mitochondrial dynamics; Interacted with insulin-like growing factor 2; mRNA-binding protein 2; mRNA stability |
| Core Tip |
We confirmed the effect of 4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (NIPSNAP1) as a new target that controls mitophagy and mitochondrial dynamics in hepatic ischemia-reperfusion. Knockdown of NIPSNAP1 impaired mitophagy and disrupted mitochondrial dynamics, as evidenced by increased mitochondrial fission and reduced fusion. Further studies revealed that interacted with insulin-like growing factor 2 acts as an n6-methyladenosine reader to bind NIPSNAP1 mRNA and enhance its stability, thereby regulating NIPSNAP1 expression. These results suggest that the interacted with insulin-like growing factor 2/NIPSNAP1 axis may be a promising target for hepatic ischemia-reperfusion. |
| Publish Date |
2025-06-12 03:45 |
| Citation |
Guo SS, Zhao Y, Hu Y, Wang XY, Zhao XZ, Zhong PY, Luan QR, Wang ZC, Yao JH. N6-methyladenosine reader IGF2BP2 regulates NIPSNAP1-mediated mitophagy and mitochondrial dynamics to alleviate hepatic ischemia-reperfusion injury. World J Gastroenterol 2025; 31(22): 105157 |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i22/105157.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i22.105157 |
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