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Articles Published Processes
6/13/2025 1:39:37 PM | Browse: 2 | Download: 0
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Received |
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2025-01-14 02:47 |
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Peer-Review Started |
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2025-01-14 02:47 |
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To Make the First Decision |
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Return for Revision |
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2025-03-19 03:17 |
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Revised |
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2025-03-31 05:32 |
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Second Decision |
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2025-04-23 02:39 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-04-23 07:17 |
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Articles in Press |
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2025-04-23 07:17 |
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Publication Fee Transferred |
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2025-04-01 10:45 |
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Edit the Manuscript by Language Editor |
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2025-04-29 04:03 |
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Typeset the Manuscript |
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2025-06-02 13:45 |
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Publish the Manuscript Online |
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2025-06-13 13:39 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Identification and validation of extracellular matrix-related genes in the progression of gastric cancer with intestinal metaplasia
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Lu Wang, Meng-Han Wang, Yao-Hong Yuan, Rui-Ze Xu, Lu Bai and Mi-Zhu Wang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Inner Mongolia Autonomous Region Health Science and Technology Program |
No. 202201441 |
| Qingmiao Plan of Baotou Medical College |
No. BYJJ-ZRQM202230 |
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| Corresponding Author |
Mi-Zhu Wang, Chief Physician, MD, Department of Gastroenterology, The Second Affiliated Hospital of Baotou Medical College, No. 30 Hude Mulin Street, Qingshan District, Baotou 300000, Inner Mongolia Autonomous Region, China. wangmizhu2008@163.com |
| Key Words |
Gastric cancer; Intestinal metaplasia; Extracellular matrix; SPARC; SERPINE1 |
| Core Tip |
This study aims to identify molecular biomarkers for predicting gastric cancer (GC) risk and monitoring intestinal metaplasia (IM) progression. Using weighted gene co-expression network analysis, 71 upregulated and 171 downregulated genes related to the extracellular matrix were identified. SPARC and SERPINE1 were found to be significant prognostic genes. A survival model integrating clinical tumor node metastasis staging, age, and SPARC/SERPINE1 expression was developed. Immunohistochemistry and Western blot analyses confirmed the elevated expression of SPARC in IM and GC. SPARC expression correlated with cancer progression and could serve as an early biomarker and therapeutic target for GC. |
| Publish Date |
2025-06-13 13:39 |
| Citation |
<p>Wang L, Wang MH, Yuan YH, Xu RZ, Bai L, Wang MZ. Identification and validation of extracellular matrix-related genes in the progression of gastric cancer with intestinal metaplasia. <i>World J Gastrointest Oncol</i> 2025; 17(6): 105160</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i6/105160.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i6.105160 |
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