| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Duodenal mucosal ablation with irreversible electroporation reduces liver lipids in rats with non-alcoholic fatty liver disease
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jia-Wei Yu, Qi Zhao, Pei-Xi Li, Ya-Xuan Zhang, Bi-Xuan Gao, Lin-Biao Xiang, Xiao-Yu Liu, Lei Wang, Yi-Jie Sun, Ze-Zhou Yang, Yu-Jia Shi, Yun-Fei Chen, Meng-Bo Yu, Hong-Ke Zhang, Lei Zhang, Qin-Hong Xu, Lu Ren, Dan Li, Yi Lyu, Feng-Gang Ren and Qiang Lu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Key Research and Development Program |
2023YFF0713700 and 2023YFF0713705 |
| Common Technology R&D Platform of Shaanxi Province |
2023GXJS-01-1-2 |
| the Cyrus Tang Foundation Chung Ying Young Scholars Program |
|
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| Corresponding Author |
Qiang Lu, MD, PhD, National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, No. 76 Yanta West Road, Xi’an 710061, Shaanxi Province, China. luqiang2020@xjtufh.edu.cn |
| Key Words |
Duodenal mucosal ablation; Irreversible electroporation; Non-alcoholic fatty liver disease; Enteroendocrine; Duodenal permeability |
| Core Tip |
This study assessed the feasibility and effectiveness of simple duodenal mucosal ablation (DMA) using irreversible electroporation (IRE) in non-alcoholic fatty liver disease rat model. After DMA using IRE, the duodenal wall structure changed and appeared to return to normal when compared to the sham-control group, while liver lipid deposition reduced and serum lipid parameters considerably improved. Also, changes in the intestinal endocrine system were observed. Therefore, by altering enteroendocrine and duodenal permeability, simple DMA using IRE ameliorated liver lipid deposition in non-alcoholic fatty liver disease rats. |
| Publish Date |
2025-04-27 03:54 |
| Citation |
<p>Yu JW, Zhao Q, Li PX, Zhang YX, Gao BX, Xiang LB, Liu XY, Wang L, Sun YJ, Yang ZZ, Shi YJ, Chen YF, Yu MB, Zhang HK, Zhang L, Xu QH, Ren L, Li D, Lyu Y, Ren FG, Lu Q. Duodenal mucosal ablation with irreversible electroporation reduces liver lipids in rats with non-alcoholic fatty liver disease. <i>World J Gastroenterol</i> 2025; 31(16): 105188</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i16/105188.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i16.105188 |
