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Articles Published Processes
7/14/2025 12:55:53 PM | Browse: 3 | Download: 14
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Received |
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2025-01-18 06:51 |
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Peer-Review Started |
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2025-01-18 06:51 |
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To Make the First Decision |
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Return for Revision |
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2025-02-26 07:42 |
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Revised |
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2025-03-12 07:45 |
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Second Decision |
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2025-04-21 02:36 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-04-21 08:36 |
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Articles in Press |
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2025-04-21 08:36 |
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Publication Fee Transferred |
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2025-03-13 05:45 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-06-27 00:52 |
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Publish the Manuscript Online |
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2025-07-14 12:55 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Nav1.6 drives colorectal cancer proliferation and invasion through MAPK signaling pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Li-Ming Zhao, Wan-Ying Hong, Jian-Guang Xu, Shui-Quan Lin, Ming-Sheng Liu, Li-Hui Wang, Xu-Li Jiang, Ming Sang and Yang-Bo Lv |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science and Technology Project of Quzhou of China |
2021Y011 |
| Beijing Science and Technology Innovation Medical Development Foundation |
KC2021-JX-0186-81 |
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| Corresponding Author |
Yang-Bo Lv, Department of Colorectal Surgery, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s Hospital, No. 100 Minjiang Avenue, Quzhou 324002, Zhejiang Province, China. lyb20110115@163.com |
| Key Words |
Nav1.6; Colorectal cancer; Weighted correlation network analysis; MAPK signaling; Cancer proliferation |
| Core Tip |
Voltage-gated sodium channels are prominently expressed in various tumors and play a crucial role in tumor metastasis and invasion. Our research identified 575 differentially expressed genes related to Nav1.6 in colorectal cancer (CRC), particularly enriched in MAPK signaling pathways. Tissue microarray revealed heightened Nav1.6 levels in CRC tissues. The cytoplasmic expression of Nav1.6 increases with T staging. Knockdown of SCN8A in colon tumor cells significantly decreased cell proliferation and invasion, along with downregulation of key proteins in the RAF-MAPK pathway. These findings suggest that Nav1.6 enhances CRC cell proliferation and invasion through modulation of the MAPK signaling pathway. |
| Publish Date |
2025-07-14 12:55 |
| Citation |
<p>Zhao LM, Hong WY, Xu JG, Lin SQ, Liu MS, Wang LH, Jiang XL, Sang M, Lv YB. Nav1.6 drives colorectal cancer proliferation and invasion through MAPK signaling pathway. <i>World J Gastrointest Oncol</i> 2025; 17(7): 105264</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i7/105264.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i7.105264 |
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