Publication Name	World Journal of Stem Cells
Manuscript ID	105266
Country	China

Received	2025-02-12 06:57
Peer-Review Started	2025-02-18 00:44
To Make the First Decision
Return for Revision	2025-03-05 09:17
Revised	2025-03-17 09:51
Second Decision	2025-04-28 01:20
Accepted by Journal Editor-in-Chief	2025-05-02 06:46
Accepted by Executive Editor-in-Chief	2025-05-09 07:15
Articles in Press	2025-05-09 07:15
Publication Fee Transferred	2025-03-21 04:53
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-05-14 05:19
Publish the Manuscript Online	2025-05-26 09:15

ISSN	1948-0210 (online)
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Category	Transplantation
Manuscript Type	Basic Study
Article Title	Human umbilical cord mesenchymal stem cells ameliorate liver metabolism in diabetic rats with metabolic-associated fatty liver disease
Manuscript Source	Unsolicited Manuscript
All Author List	Ke-Bing Zhou, Li Nie, Mei-Li Wang, Dong-Hua Xiao, Hai-Yan Zhang, Xia Yang, Duan-Fang Liao and Xue-Feng Yang
ORCID	Author(s) ORCID Number Ke-Bing Zhou http://orcid.org/0009-0009-2031-916X Li Nie http://orcid.org/0009-0003-1380-047X Mei-Li Wang http://orcid.org/0009-0000-4054-6882 Dong-Hua Xiao http://orcid.org/0009-0008-0916-0605 Hai-Yan Zhang http://orcid.org/0009-0003-3037-9074 Xia Yang http://orcid.org/0000-0002-2912-2410 Duan-Fang Liao http://orcid.org/0000-0002-3434-3832 Xue-Feng Yang http://orcid.org/0000-0002-3470-0350
Funding Agency and Grant Number	Funding Agency Grant Number National Key Specialty Major Scientific Research Project of the Hunan Provincial Health Commission Z2023158
Corresponding Author	Xue-Feng Yang, PhD, Professor, Department of Gastroenterology, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, No. 336 Dongfeng South Road, Zhuhui District, Hengyang 421002, Hunan Province, China. yxf9988@126.com
Key Words	Human umbilical cord mesenchymal stem cells; Diabetes mellitus; Metabolic-associated fatty liver disease; Blood glucose; Triglyceride; Liver function; Liver metabolism
Core Tip	Current treatment methods for diabetes mellitus (DM) with metabolic-associated fatty liver disease (MAFLD) remain limited, and there is an urgent need to identify novel and effective therapeutic strategies. In this study, a rat model of DM with MAFLD was established using streptozotocin, and human umbilical cord mesenchymal stem cell were administered via tail vein injection as an intervention. Our findings showed that human umbilical cord mesenchymal stem cell alleviate liver metabolic disturbances in diabetic rats with MAFLD, consequently mitigating the pathological state of DM and slowing the progression of MAFLD.
Publish Date	2025-05-26 09:15
Citation	<p>Zhou KB, Nie L, Wang ML, Xiao DH, Zhang HY, Yang X, Liao DF, Yang XF. Human umbilical cord mesenchymal stem cells ameliorate liver metabolism in diabetic rats with metabolic-associated fatty liver disease. <i>World J Stem Cells</i> 2025; 17(5): 105266</p>
URL	https://www.wjgnet.com/1948-0210/full/v17/i5/105266.htm
DOI	https://dx.doi.org/10.4252/wjsc.v17.i5.105266

Full Article (PDF)	WJSC-17-105266-with-cover.pdf
The ARRIVE Guidelines	105266-The-ARRIVE-Guidelines.pdf
Manuscript File	105266_Auto_Edited_091834.docx
Answering Reviewers	105266-answering-reviewers.pdf
Audio Core Tip	105266-audio.mp3
Biostatistics Review Certificate	105266-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	105266-conflict-of-interest-statement.pdf
Copyright License Agreement	105266-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	105266-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	105266-institutional-animal-care-and-use-committee-statement.pdf
Institutional Review Board Approval Form or Document	105266-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	105266-non-native-speakers.pdf
Supplementary Material	105266-supplementary-material.pdf
Peer-review Report	105266-peer-reviews.pdf
Journal Editor-in-Chief Review Report	105266-journal-editor-in-chief.pdf
Scientific Misconduct Check	105266-scientific-misconduct-check.png
Scientific Editor Work List	105266-scientific-editor-work-list.pdf
CrossCheck Report	105266-crosscheck-report.pdf