| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Clinical characteristics and risk factors of esophageal reflux hypersensitivity: A multicenter study
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yan-Ping Wu, Jia-Xuan Zhou, Hong-Bo Wu, Di-Ping Wu, Ling-Zhi Qin, Bin Qin, Xiao-Yu Xu, Saleh Abdulaziz Abdulgani Yehya and Yan Cheng |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Foundation of the Second Affiliated Hospital of Xi’an Jiaotong University |
YJ(ZD)202301 |
|
| Corresponding Author |
Yan Cheng, Chief Physician, PhD, Professor, Department of Gastroenterology, The Second Affiliated Hospital of Xi’an Jiaotong University, No. 157 Xiwu Street, Xi’an 710000, Shaanxi Province, China. 15609264849@163.com |
| Key Words |
Gastroesophageal reflux disease; Functional esophageal disease; Reflux hypersensitivity; Clinical characteristics; Risk factors |
| Core Tip |
Reflux hypersensitivity (RH) significantly contributes to heartburn. However, its underlying mechanisms are not fully comprehended. This retrospective study examined data from 92 patients diagnosed with RH and 104 healthy controls to explore clinical characteristics and potential risk factors. The results demonstrate that weakly acidic reflux and nonacidic reflux are integral to the pathophysiology of RH. Furthermore, extraesophageal symptoms were correlated with a younger age and elevated levels of nonacidic reflux. Independent risk factors identified for RH encompass age, the existence of a hiatal hernia, and anxiety. These findings highlight the intricate relationship between reflux subtypes and psychological factors in RH, offering new perspectives for individualized diagnostic and therapeutic strategies. |
| Publish Date |
2025-04-29 09:13 |
| Citation |
<p>Wu YP, Zhou JX, Wu HB, Wu DP, Qin LZ, Qin B, Xu XY, Yehya SAA, Cheng Y. Clinical characteristics and risk factors of esophageal reflux hypersensitivity: A multicenter study. <i>World J Gastroenterol</i> 2025; 31(17): 105281</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i17/105281.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i17.105281 |
