| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Diagnostic value of alpha-fetoprotein and prothrombin induced by vitamin K absence-II in serum, bile, feces in hepatocellular carcinoma
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zi-Jun Chen, Xiang-Kun Wang, Chuang-Ye Han, Yong-Fei He, Tian-Yi Liang, Shu-Tian Mo, Guang-Zhi Zhu, Cheng-Kun Yang, Xin-Ping Ye, Zi-Li Lv, Shi-Fu Pang, Xiao-Dong Chen, Peng Wang and Tao Peng |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Tao Peng, MD, PhD, Professor, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. pengtaogmu@163.com |
| Key Words |
Hepatocellular carcinoma; Alpha-fetoprotein; Prothrombin induced by vitamin K absence-II; Bile biomarkers; Serum biomarkers; Diagnosis; Receiver operating characteristic analysis; Gut-liver axis |
| Core Tip |
This study evaluated the diagnostic potential of various biomarkers for hepatocellular carcinoma (HCC) with serum prothrombin induced by vitamin K absence-II (PIVKA-II) showing the highest diagnostic accuracy. However, serum alpha-fetoprotein (AFP) was more accurate for early HCC diagnosis. Bile AFP could improve diagnostic performance and its combination with PIVKA-II achieved the highest area under the curve for HCC detection. Additionally, bile AFP was associated with poorer HCC clinical outcomes. |
| Publish Date |
2025-05-15 10:28 |
| Citation |
<p>Chen ZJ, Wang XK, Han CY, He YF, Liang TY, Mo ST, Zhu GZ, Yang CK, Ye XP, Lv ZL, Pang SF, Chen XD, Wang P, Peng T. Diagnostic value of alpha-fetoprotein and prothrombin induced by vitamin K absence-II in serum, bile, feces in hepatocellular carcinoma. <i>World J Gastrointest Oncol</i> 2025; 17(5): 105311</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i5/105311.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i5.105311 |
