| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
LncRNA SNHG5 modulates cell proliferation and migration through the miR-92a-3p/BTG2 axis in gastric cancer by the PI3K/AKT pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Qi-Qi Mao, Mei-Lin Zhang, Liang Zhong, Xu-Dong Xu, Xin-Hai Wang, Du-Yi Pan, Fu-Sheng Zhou, Jia-Xin Huang, Xian-Guang Zhao, Jia-Jie Chen, Xiao-Yun Jiang, Xu Sun and Wei-Qun Ding |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Liang Zhong, Chief Physician, Department of Gastroenterology, Huashan Hospital, Fudan University, No. 12 Urumqi Middle Road, Shanghai 201907, China. ifb422@yeah.net |
| Key Words |
PI3K/AKT signaling pathway; B-cell translocation gene 2; Gastric cancer; Long non-coding RNAs small nucleolar RNA host gene 5; Non-coded RNA; Cell proliferation |
| Core Tip |
This study emphasizes the role of lncRNA SNHG5 as a tumor-suppression factor in gastric cancer (GC). SNHG5 acts as a competing endogenous RNA by reducing levels of miR-92a-3p, leading to increased levels of BTG2, a tumor suppressor gene. This ultimately leads to the inhibition of GC cell proliferation and migration by inhibiting the PI3K/AKT signaling pathway. This is the first time that an SNHG5/miR-92a-3p/BTG2 axis has been discovered to contribute to the progression of GC. This molecular understanding aids in providing an attractive target for therapy and will contribute to a framework of RNA-based approaches to diagnosing and treating GC. |
| Publish Date |
2025-08-14 05:49 |
| Citation |
<p>Mao QQ, Zhang ML, Zhong L, Xu XD, Wang XH, Pan DY, Zhou FS, Huang JX, Zhao XG, Chen JJ, Jiang XY, Sun X, Ding WQ. LncRNA SNHG5 modulates cell proliferation and migration through the miR-92a-3p/BTG2 axis in gastric cancer by the PI3K/AKT pathway. <i>World J Gastrointest Oncol</i> 2025; 17(8): 105321</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i8/105321.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i8.105321 |
