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Articles Published Processes
5/14/2025 5:24:52 AM | Browse: 5 | Download: 7
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Received |
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2025-01-18 07:19 |
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Peer-Review Started |
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2025-01-18 07:19 |
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To Make the First Decision |
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Return for Revision |
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2025-03-25 03:16 |
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Revised |
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2025-04-01 12:14 |
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Second Decision |
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2025-04-09 02:40 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-04-09 07:48 |
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Articles in Press |
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2025-04-09 07:48 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-05-06 02:22 |
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Publish the Manuscript Online |
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2025-05-14 05:24 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Immunoglobulin G4 biomarkers and pathogenesis in immunoglobulin G4-related spinal pachymeningitis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Abdellatif Bouayad and Ahmed Amine El Oumri |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Abdellatif Bouayad, Associate Professor, MD, Laboratory of Immunology, Faculty of Medicine and Pharmacy Oujda, Morocco, 4867 Oujda l’Université, Oujda-Angad 4867, Oriental, Morocco. a.bouayad@ump.ac.ma |
| Key Words |
IgG4-related spinal pachymeningitis; Serum IgG4; Cerebrospinal fluid IgG4; IgG4 indices; Pathogenesis |
| Core Tip |
Immunoglobulin G4 (IgG4)-related spinal pachymeningitis is a rare inflammatory disorder affecting the spinal dura mater. Although increased serum IgG4 levels are commonly reported, they lack specificity when used in isolation. Cerebrospinal fluid-based biomarkers, such as the IgG4 indices and the presence of IgG4-specific oligoclonal bands, may provide a reliable alternative to meningeal biopsy, particularly when the latter is contraindicated or yields inconclusive results. These biomarkers offer advantages in terms of cost, accessibility, sensitivity, and specificity. Clarifying the pathogenic vs regulatory role of IgG4 is critical for both diagnosis and treatment. |
| Publish Date |
2025-05-14 05:24 |
| Citation |
<p>Bouayad A, El Oumri AA. Immunoglobulin G4 biomarkers and pathogenesis in immunoglobulin G4-related spinal pachymeningitis. <i>World J Clin Cases</i> 2025; 13(22): 105331</p> |
| URL |
https://www.wjgnet.com/2307-8960/full/v13/i22/105331.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v13.i22.105331 |
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