Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	10534
Country	India

Received	2014-04-08 11:11
Peer-Review Started	2014-04-08 18:32
To Make the First Decision
Return for Revision
Revised
Second Decision	2014-05-09 10:10
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-05-09 10:26
Articles in Press	2014-05-23 12:20
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-05-13 23:56
Typeset the Manuscript	2014-06-13 13:59
Publish the Manuscript Online	2014-06-20 15:55

ISSN	1948-5204 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Systematic Reviews
Article Title	Current status of pharmacological treatment of colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Reyhan Akhtar, Shammy Chandel, Pooja Sarotra and Bikash Medhi
Funding Agency and Grant Number
Corresponding Author	Bikash Medhi, MD, Additional Professor, Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India. drbikashus@yahoo.com
Key Words	Colorectal cancer; Metastasis; Chemotherapy; 5-fluorouracil; Leucovorin; Epidermal growth factor receptor inhibitor
Core Tip	A systematic review was undertaken to identify randomized controlled trials (RCTs) assessing synthetic drugs for the treatment of colorectal cancer and/or adenomatous polyps from various medical databases, including clinicaltrials.gov, and a total of around 2300 RCTs were screened. After reviewing data from RCTs of synthetic drugs, alone or in combination with biological agents, for the treatment of colorectal cancer, it was concluded that combination regimens of standard chemotherapeutic drugs with new cytotoxic and targeted agents have led to an increase in overall and progression-free survival and have also contributed to increased rates of resectability and improved health-related quality of life in patients.
Publish Date	2014-06-20 15:55
Citation	Akhtar R, Chandel S, Sarotra P, Medhi B. Current status of pharmacological treatment of colorectal cancer. World J Gastrointest Oncol 2014; 6(6): 177-183
URL	http://www.wjgnet.com/1948-5204/full/v6/i6/177.htm
DOI	http://dx.doi.org/10.4251/wjgo.v6.i6.177

Full Article (PDF)	WJGO-6-177.pdf
Full Article (Word)	WJGO-6-177.doc
Manuscript File	10534-Review.docx
Answering Reviewers	10534-Answering reviewers.pdf
Copyright License Agreement	10534-Copyright assignment.PDF
Peer-review Report	10534-Peer review(s).pdf
Scientific Editor Work List	10534-Scientific editor work list.doc