Publication Name	World Journal of Gastroenterology
Manuscript ID	10537
Country	China

Received	2014-04-06 11:28
Peer-Review Started	2014-04-06 18:25
First Decision by Editorial Office Director
Return for Revision	2014-05-21 08:48
Revised	2014-06-22 00:00
Publication Fee Transferred
Second Decision by Editor	2014-07-11 16:58
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-07-11 17:24
Articles in Press	2014-07-11 17:36
Edit the Manuscript by Language Editor	2014-07-19 03:59
Typeset the Manuscript	2014-12-10 12:24
Publish the Manuscript Online	2014-12-20 19:42

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Review
Article Title	Cancer-associated fibroblasts in digestive tumors
Manuscript Source	Unsolicited Manuscript
All Author List	Lei Huang, A-Man Xu, Sha Liu, Wei Liu and Tuan-Jie Li
Funding Agency and Grant Number
Corresponding Author	Lei Huang, MD, Department of Gastrointestinal Surgery, the First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei 230022, Anhui Province, China. huangleizhenting@126.com
Key Words	Cancer-associated fibroblast; Tumor progression; Epithelial-mesenchymal transition; Tumor immunity; Targeted therapy
Core Tip	As a dominant component in tumor stroma, CAFs promote tumorigenesis, and tumor progression by stimulating angiogenesis, malignant cell survival, EMT and proliferation via direct cell-to-cell contact or secretion of soluble factors in most digestive solid tumors. CAFs are characterized by expressions of α-SMA, FAP, FSP, vimentin, etc. They are hypothesized to originate from various cells. EMT may also be an important process generating CAFs. There exists a close link between CAFs-induced EMT, chemo-resistance of tumor cells, and tumor stem cells. CAFs significantly induce immunosuppression, and could be a prognostic marker. Targeted therapy toward CAFs has displayed promising anticancer efficacy.
Publish Date	2014-12-20 19:42
Citation	Huang L, Xu AM, Liu S, Liu W, Li TJ. Cancer-associated fibroblasts in digestive tumors. World J Gastroenterol 2014; 20(47): 17804-17818
URL	http://www.wjgnet.com/1007-9327/full/v20/i47/17804.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i47.17804

Full Article (PDF)	WJG-20-17804.pdf
Full Article (Word)	WJG-20-17804.doc
Manuscript File	10537-Review.doc
Answering Reviewers	10537-Answering reviewers.pdf
Copyright License Agreement	10537-Copyright assignment.pdf
Peer-review Report	10537-Peer reviews.pdf
Scientific Misconduct Check	10537-CrossCheck.jpg
Scientific Editor Work List	10537-Scientific editor work list.pdf