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Articles Published Processes
9/1/2025 8:05:39 AM | Browse: 26 | Download: 7
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Received |
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2025-01-23 06:07 |
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Peer-Review Started |
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2025-01-23 06:07 |
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To Make the First Decision |
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Return for Revision |
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2025-04-09 06:39 |
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Revised |
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2025-06-02 02:39 |
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Second Decision |
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2025-08-14 03:14 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-08-15 05:55 |
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Articles in Press |
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2025-08-15 05:55 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-08-25 09:56 |
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Publish the Manuscript Online |
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2025-09-01 08:05 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Focal adhesion kinase: A promising regulator of colitis-associated healing
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Kaitlyn Kaye Malek, Balawant Kumar, Rizwan Ahmad, Amar Singh and Marc D Basson |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Marc D Basson, College of Medicine, Northeast Ohio Medical University, 4209 State Route 44, Rootstown, OH 44272, United States. mbasson@neomed.edu |
| Key Words |
Focal adhesion kinase; Inflammatory bowel disease; Mucosal healing; Gut barrier integrity; Colitis pathophysiology |
| Core Tip |
Focal adhesion kinase (FAK) plays a critical role in gastrointestinal mucosal healing via various key cellular processes. Small molecule FAK activators, such as ZINC40099027 or analogs, selectively enhance the activity of FAK to promote epithelial cell migration and wound closure. Therefore, ZINC40099027 and similar agents demonstrate promise in treating gastrointestinal mucosal injuries, such as ulcers or inflammatory bowel disease. Their two-fold approach in perpetuating repair mechanisms while minimizing oncogenic pathogenesis offers a therapeutic solution that is a safer, long-term treatment option for complex mucosal injuries. |
| Publish Date |
2025-09-01 08:05 |
| Citation |
<p>Malek KK, Kumar B, Ahmad R, Singh A, Basson MD. Focal adhesion kinase: A promising regulator of colitis-associated healing. <i>World J Gastroenterol</i> 2025; 31(33): 105466</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i33/105466.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i33.105466 |
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