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Articles Published Processes
11/28/2025 2:00:37 PM | Browse: 119 | Download: 279
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Received |
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2025-01-27 15:16 |
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Peer-Review Started |
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2025-01-27 15:17 |
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First Decision by Editorial Office Director |
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2025-03-19 03:42 |
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Return for Revision |
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2025-03-19 03:42 |
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Revised |
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2025-04-16 02:34 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-06-03 02:55 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-06-03 08:59 |
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Articles in Press |
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2025-06-03 08:59 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-11-13 07:34 |
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Publish the Manuscript Online |
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2025-11-28 14:00 |
| ISSN |
2220-3141(online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Critical Care Medicine |
| Manuscript Type |
Minireviews |
| Article Title |
Sepsis and the diverse organ-gastrointestinal tract axis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Jia Dong James Wang, Enhui Suan, Sean Siwei Li and Vishal G Shelat |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Vishal G Shelat, Department of General Surgery, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore. vgshelat@gmail.com |
| Key Words |
Critical care; Gut microbiota dysbiosis; Multi-organ dysfunction; Organ-gut axis; Sepsis |
| Core Tip |
This review underscores the critical role of gut microbiota in sepsis pathophysiology, revealing how gut dysbiosis exacerbates multi-organ dysfunction via organ-gut axes (gut-liver, gut-lung, gut-brain, gut-kidney, and gut-heart). Innovative microbiota-targeted therapies, such as probiotics, prebiotics, and fecal microbiota transplantation, show potential to restore microbial balance, reduce systemic inflammation, and improve outcomes. By synthesizing current evidence, this manuscript provides a foundation for integrating microbiota-based approaches into sepsis management frameworks, offering a novel perspective for mitigating the global burden of sepsis. |
| Publish Date |
2025-11-28 14:00 |
| Citation |
Wang JDJ, Suan E, Li SS, Shelat VG. Sepsis and the diverse organ-gastrointestinal tract axis. World J Crit Care Med 2025; 14(4): 105547 |
| URL |
https://www.wjgnet.com/2220-3141/full/v14/i4/105547.htm |
| DOI |
https://dx.doi.org/10.5492/wjccm.v14.i4.105547 |
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