| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Multi-parameter magnetic resonance imaging of zebularine in liver fibrosis treatment and calcineurin/NFAT3 mechanism
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shi-Yi Lyu, Wang Xiao, Yan-Jing Chen, Qiu-Ling Liao, Ye-Yu Cai, Cheng Yu, Jia-Yi Liu, Huan Liu, Min-Ping Zhang, Yu-Lu Ren, Qi-Ling Yu, Yi-Ming Qi, En-Hua Xiao and Yong-Heng Luo |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Health Research Foundation of Hunan Provincial Health Commission |
No. W20243192 |
| Natural Science Foundation of Changsha |
No. kq2403086 |
| National Natural Science Foundation of China |
No. 81571784 |
| Hunan Provincial Health Commission Hunan Provincial High-level Health Talent Major Scientific Research Project |
No. R2023022 |
|
| Corresponding Author |
Yong-Heng Luo, Department of Radiology, Second Xiangya Hospital of Central South University, No. 139 Renming Middle Road, Changsha 410011, Hunan Province, China. luoyongheng@csu.edu.cn |
| Key Words |
Zebularine; Regulator of calcineurin1.4; Calcineurin/NFAT3 pathway; Hepatic stellate cell; Liver fibrosis; DNA methylation |
| Core Tip |
This study explored zebularine’s role in liver fibrosis. Given that hepatic stellate cell activation drives fibrosis and zebularine’s potential via calcineurin/NFAT3, it aimed to clarify its mechanism and efficacy using multiparametric magnetic resonance imaging (MRI). In vitro and in vivo tests showed zebularine regulated genes, inhibited the pathway, and reduced fibrosis, with MRI validating its efficacy. |
| Publish Date |
2025-05-28 07:32 |
| Citation |
<p>Lyu SY, Xiao W, Chen YJ, Liao QL, Cai YY, Yu C, Liu JY, Liu H, Zhang MP, Ren YL, Yu QL, Qi YM, Xiao EH, Luo YH. Multi-parameter magnetic resonance imaging of zebularine in liver fibrosis treatment and calcineurin/NFAT3 mechanism. <i>World J Gastroenterol</i> 2025; 31(20): 105554</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i20/105554.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i20.105554 |
