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Articles Published Processes
6/13/2025 1:39:41 PM | Browse: 45 | Download: 392
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Received |
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2025-02-18 08:47 |
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Peer-Review Started |
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2025-02-18 08:47 |
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First Decision by Editorial Office Director |
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2025-03-06 07:09 |
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Return for Revision |
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2025-03-06 07:09 |
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Revised |
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2025-03-28 08:40 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-05-08 02:45 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-05-08 07:40 |
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Articles in Press |
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2025-05-08 07:40 |
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Edit the Manuscript by Language Editor |
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2025-05-12 01:59 |
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Typeset the Manuscript |
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2025-06-03 09:04 |
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Publish the Manuscript Online |
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2025-06-13 13:39 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pharmacology & Pharmacy |
| Manuscript Type |
Basic Study |
| Article Title |
Oxocrebanine inhibits the proliferation of hepatocellular carcinoma cells by promoting apoptosis and autophagy
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zheng-Wen Wang, Cai-Yan Pan, Cang-Long Wei, Hui Liao, Xiao-Po Zhang, Cai-Yun Zhang and Lei Yu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82060778 |
| the Hainan Provincial Natural Science Foundation of China |
820RC776 |
| the Hainan Province Health Science and Technology Innovation Joint Project |
WSJK2024MS162 |
| the Heilongjiang Province Scientific Research Project of Traditional Chinese Medicine |
ZHY2024-098 |
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| Corresponding Author |
Cai-Yun Zhang, Senior Researcher, Hainan Pharmaceutical Research and Development Science and Technology Park, Hainan Pharmaceutical Research and Development Science and Technology Park, Intersection of mei'an 3rd Street and anling 3rd road, Xiu Ying District, Haikou, 570312, China, Haikou 570312, Hainan Province, China. zhangcaiyunhaikou@163.com |
| Key Words |
Stephania hainannensis H.S. Lo et Y. Tsoong; Oxocrebanine; Hepatoma cancer Hep3B2.1-7 cells; Apoptosis; Autophagy |
| Core Tip |
The present study revealed that oxocrebanine can inhibit the proliferation of hepatoma cells by promoting apoptosis and inducing autophagy both in vitro and in vivo. Oxocrebanine can induce apoptosis in Hep3b2.1-7 cells upregulating c-caspase-3, Bax, and Bak protein expression levels and downregulating PARP1, Bcl-2, and Mcl-1 protein expression levels. The inhibition of Hep3b2.1-7 cells proliferation by oxocrebanine may be related to the induction of protective autophagy. The results of the TUNEL assay and immunohistochemistry also revealed that oxocrebanine induced apoptosis in vivo and increased the expression level of LC3, an autophagy marker. |
| Publish Date |
2025-06-13 13:39 |
| Citation |
Wang ZW, Pan CY, Wei CL, Liao H, Zhang XP, Zhang CY, Yu L. Oxocrebanine inhibits the proliferation of hepatocellular carcinoma cells by promoting apoptosis and autophagy. World J Gastrointest Oncol 2025; 17(6): 105570 |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i6/105570.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i6.105570 |
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