| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Prospective Study |
| Article Title |
Identification and validation of serum amino acids as diagnostic biomarkers for diabetic peripheral neuropathy
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wei-Sheng Xu, Huan Xing, Qing-Qing Wang, Hui Qi, Jian-Tao He, Tong Jin, Yan-Peng Kan, Shi-Yu Sun, Ji-Ying Wang and Fu-Qing Lin |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Youth Fund for Specialized Clinical Research of the Health Commission |
20214Y0149 |
|
| Corresponding Author |
Fu-Qing Lin, Chief Physician, Department of Pain Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No. 301 Yanchang Middle Road, Jingan District, Shanghai 200072, China. fuqinglin@tongji.edu.cn |
| Key Words |
Diabetic peripheral neuropathy; Type 2 diabetes mellitus; Arginine; Tyrosine; Glutamic acid |
| Core Tip |
This study involves the most extensive identification of serum amino acids as biomarkers for the detection of diabetic peripheral neuropathy (DPN), including the use of both training and validation cohorts. This is the first study demonstrating that a signature consisting of 3 serum amino acids (arginine, tyrosine, and glutamic acid) and diabetes duration can successfully distinguish DPN from type 2 diabetes mellitus with acceptable accuracy. Thirteen DPN patients received treatment in our department, and their clinical symptoms were relieved; moreover, their serum arginine and tyrosine levels were significantly increased, which may reflect the reliability of our model. These findings may provide potential therapeutic targets for the diagnosis and treatment of DPN. |
| Publish Date |
2025-06-13 11:47 |
| Citation |
<p>Xu WS, Xing H, Wang QQ, Qi H, He JT, Jin T, Kan YP, Sun SY, Wang JY, Lin FQ. Identification and validation of serum amino acids as diagnostic biomarkers for diabetic peripheral neuropathy. <i>World J Diabetes</i> 2025; 16(6): 105592</p> |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i6/105592.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i6.105592 |
