| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pediatrics |
| Manuscript Type |
Basic Study |
| Article Title |
Combined detection of P53, Ki67, P504S, and IMP3: Diagnostic implications for gastric cancer and precursor lesions
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Lan-Fang Miao, Yuan-Yuan Sun, Xian-Juan Du, Nan Xu, Jing-Wei Shen, Hui Hua, Mei Guo, Hai-Jun Yang, Jun-Kuo Li and Lei Zhu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The Science and Technology Research Project of Anyang |
2022C01SF074 |
|
| Corresponding Author |
Lan-Fang Miao, Associate Chief Physician, Department of Pathology, Anyang Tumor Hospital, No. 1 Huanbin Road, Anyang 455000, Henan Province, China. lanfang_miao@163.com |
| Key Words |
Gastric mucosal biopsy; Precursor lesions; IMP3; P504S; P53; Ki67 |
| Core Tip |
The combined detection of P504S and Ki67 for low-grade dysplasia (LGD), and IMP3 and P53 for high-grade dysplasia (HGD) and adenocarcinoma (AC), enhances diagnostic sensitivity, aiding in the differentiation of gastric cancer and its precancerous lesions, thereby improving early cancer diagnosis. Immunohistochemical markers P504S, Ki67, IMP3, and P53 are valuable in distinguishing gastric lesions, including atypical hyperplasia (AH), LGD, HGD, and AC. P504S is predominantly expressed in LGD and shows a correlation with the Ki67 “polarity” expression pattern, while IMP3 is highly expressed in HGD/AC and correlates with the P53 mutation pattern. The combined detection of P504S with Ki67 and IMP3 with P53 significantly enhances the diagnostic sensitivity of LGD and HGD/AC, aiding in the early detection of gastric cancer and its precancerous lesions. This approach can improve the accuracy of pathological diagnoses, thereby facilitating timely intervention. |
| Publish Date |
2025-05-15 10:29 |
| Citation |
<p>Miao LF, Sun YY, Du XJ, Xu N, Shen JW, Hua H, Guo M, Yang HJ, Li JK, Zhu L. Combined detection of P53, Ki67, P504S, and IMP3: Diagnostic implications for gastric cancer and precursor lesions. <i>World J Gastrointest Oncol</i> 2025; 17(5): 105604</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i5/105604.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i5.105604 |
