Publication Name	World Journal of Diabetes
Manuscript ID	105615
Country	Kuwait

Received	2025-01-30 14:33
Peer-Review Started	2025-01-30 14:33
To Make the First Decision
Return for Revision	2025-03-26 05:59
Revised	2025-04-03 08:59
Second Decision	2025-05-12 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-12 09:04
Articles in Press	2025-05-12 09:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-06-06 01:12
Publish the Manuscript Online	2025-06-13 11:47

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Medicine, Research & Experimental
Manuscript Type	Editorial
Article Title	Epigenetics and diabetic wound healing: Wilms tumor 1-associated protein as a therapeutic target
Manuscript Source	Invited Manuscript
All Author List	Ashraf Al Madhoun
ORCID	Author(s) ORCID Number Ashraf Al Madhoun http://orcid.org/0000-0001-8593-3878
Funding Agency and Grant Number	Funding Agency Grant Number The Kuwait Foundation for the Advancement of Sciences RACB-2021-007
Corresponding Author	Ashraf Al Madhoun, PhD, Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Jassim AlBahar Street, Dasman 15400, Kuwait. ashraf.madhoun@dasmaninstitute.org
Key Words	Diabetic foot ulcers; Epigenetics; Wilms tumor 1-associated protein; DNA methyltransferase 1; M6A modification; Wound healing
Core Tip	Xiao et al identified the Wilms tumor 1-associated protein (WTAP) - DNA methyltransferase 1 (DNMT1) axis as a pivotal regulator of diabetic foot ulcer healing. Using human umbilical vein endothelial cells and a diabetic mouse model, those researchers demonstrated that WTAP knockdown restored endothelial cell function and enhanced angiogenesis and collagen deposition. Importantly, siRNA-mediated WTAP depletion markedly improved wound closure in the diabetic mice. Furthermore, DNMT1 reversed the beneficial effects of WTAP knockdown, confirming that it is a key downstream effector of WTAP.
Publish Date	2025-06-13 11:47
Citation	<p>Al Madhoun A. Epigenetics and diabetic wound healing: Wilms tumor 1-associated protein as a therapeutic target. <i>World J Diabetes</i> 2025; 16(6): 105615</p>
URL	https://www.wjgnet.com/1948-9358/full/v16/i6/105615.htm
DOI	https://dx.doi.org/10.4239/wjd.v16.i6.105615

Full Article (PDF)	WJD-16-105615-with-cover.pdf
Manuscript File	105615_Auto_Edited_080701.docx
Answering Reviewers	105615-answering-reviewers.pdf
Audio Core Tip	105615-audio.mp3
Conflict-of-Interest Disclosure Form	105615-conflict-of-interest-statement.pdf
Copyright License Agreement	105615-copyright-assignment.pdf
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Non-Native Speakers of English Editing Certificate	105615-non-native-speakers.pdf
Peer-review Report	105615-peer-reviews.pdf
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Scientific Editor Work List	105615-scientific-editor-work-list.pdf
CrossCheck Report	105615-crosscheck-report.pdf