| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Kushenol I combats ulcerative colitis via intestinal barrier preservation and gut microbiota optimization
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xu-Dong He, Min Li, Xiang-Duo Zuo, Hao-Yu Ni, Yu-Xin Han, Yun-Kai Hu, Jie Yu and Xing-Xin Yang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82060707 |
| National Natural Science Foundation of China |
No. 82104381 |
| Application and Basis Research Project of Yunnan China |
No. 202201AW070016 |
| Application and Basis Research Project of Yunnan China |
No. 202407AB110018 |
| Engineering Research Center of Yunnan Education Department |
No. 2022YGG03 |
| Open Research Fund Program of Yunnan Key Laboratory of Integrated Traditional Chinese and Western Medicine for Chronic Disease in Prevention and Treatment |
No. 2019DG016 |
|
| Corresponding Author |
Xing-Xin Yang, Professor, College of Pharmaceutical Science, Yunnan University of Chinese Medicine, No. 1076 Yuhua Road, Kunming 650500, Yunnan Province, China. yxx78945@163.com |
| Key Words |
Kushenol I; Ulcerative colitis; Gut microbiota; Sophora flavescens Aiton; Network pharmacology; Intestinal integrity |
| Core Tip |
Kushenol I (KSCI) from Sophora flavescens shows promise for treating ulcerative colitis (UC). Network pharmacology reveals 192 potential targets, including protein kinase B, NOD-like receptor thermal protein domain associated protein 3, Toll-like receptor 4, phosphoinositide 3-kinase and forkhead box O1. In UC mice, KSCI alleviates symptoms, reduces pro-inflammatory cytokines, enhances anti-inflammatory activity, and inhibits the activation of key signaling pathways. It also exerts antioxidant effects, repairs intestinal barrier damage, and modulates the gut microbiota. Additionally, KSCI regulates T-cell balance. These findings highlight KSCI’s multi-target mechanism offering potential as a therapeutic agent for UC. |
| Publish Date |
2025-07-11 07:47 |
| Citation |
<p>He XD, Li M, Zuo XD, Ni HY, Han YX, Hu YK, Yu J, Yang XX. Kushenol I combats ulcerative colitis via intestinal barrier preservation and gut microbiota optimization. <i>World J Gastroenterol</i> 2025; 31(26): 105656</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i26/105656.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i26.105656 |
