| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Correlation between the interleukin-36 subfamily and gut microbiota in patients with liver cirrhosis: Implications for gut-liver axis imbalance
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi-Zhi Pan, Wan-Ting Chen, Hao-Ran Jin, Zhen Liu, Ying-Ying Gu, Xin-Ruo Wang, Jue Wang, Jing-Jing Lin, Yan Zhou and Lan-Man Xu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Key Project of the Ningbo Natural Science Foundation, Zhejiang Province, China |
2022J253 |
| Key Technology R&D Project of Ningbo City |
2023Z208 |
| Traditional Chinese Medicine project, Zhejiang Province, China |
2024ZF028 |
| the Key Project of Health Science and Technology Foundation , Zhejiang Province, China |
WKJ-ZJ-2551 |
|
| Corresponding Author |
Lan-Man Xu, Chief Physician, MD, PhD, Professor, Department of Infectious Diseases and Liver Diseases, Lihuili Hospital of Ningbo University, No. 1111 Jiangnan Road, High-tech Zone, Ningbo 315000, Zhejiang Province, China. 13587646315@163.com |
| Key Words |
Interleukin-36; Interleukin-36γ; Interleukin-38; Liver cirrhosis; Gut microbiota |
| Core Tip |
This study investigated the clinical relevance of serum interleukin-36 (IL-36) subfamily levels and their correlation with gut microbiota in 61 patients with liver cirrhosis (LC) and 29 healthy controls. We found that IL-36α, IL-36γ, IL-36Ra, and IL-38 Levels were significantly higher in cirrhosis patients and strongly correlated with disease progression. These cytokines may serve as novel predictive markers for LC. Our findings highlight the potential of IL-36 subfamily members as diagnostic biomarkers, contributing valuable insights to the field. |
| Publish Date |
2025-04-25 08:23 |
| Citation |
<p>Pan YZ, Chen WT, Jin HR, Liu Z, Gu YY, Wang XR, Wang J, Lin JJ, Zhou Y, Xu LM. Correlation between the interleukin-36 subfamily and gut microbiota in patients with liver cirrhosis: Implications for gut-liver axis imbalance. <i>World J Hepatol</i> 2025; 17(4): 105660</p> |
| URL |
https://www.wjgnet.com/1948-5182/full/v17/i4/105660.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i4.105660 |
