Publication Name	World Journal of Psychiatry
Manuscript ID	105751
Country	China

Received	2025-02-10 08:05
Peer-Review Started	2025-02-10 08:05
To Make the First Decision
Return for Revision	2025-03-19 07:48
Revised	2025-04-02 04:54
Second Decision	2025-04-21 13:23
Accepted by Journal Editor-in-Chief	2025-04-25 09:14
Accepted by Executive Editor-in-Chief	2025-04-27 09:07
Articles in Press	2025-04-27 09:07
Publication Fee Transferred	2025-04-07 02:44
Edit the Manuscript by Language Editor	2025-05-13 12:00
Typeset the Manuscript	2025-05-20 07:03
Publish the Manuscript Online	2025-05-29 09:14

ISSN	2220-3206 (online)
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Category	Anatomy & Morphology
Manuscript Type	Basic Study
Article Title	Increased expression of the neuroplastin 65 protein is involved in neurofibrillary tangles and amyloid beta plaques in Alzheimer’s disease
Manuscript Source	Unsolicited Manuscript
All Author List	Ya-Ni Zheng, Yan Wang, Ling Chen, Li-Zhang Xu, Lei Zhang, Jia-Lu Wang, Juan Liu, Qi-Lei Zhang and Qiong-Lan Yuan
ORCID	Author(s) ORCID Number Ya-Ni Zheng http://orcid.org/0009-0004-7922-904X Qiong-Lan Yuan http://orcid.org/0000-0002-5417-1652
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 81771441 and No. 81371213 Natural Science Foundation of Shanghai No. 21ZR1468400
Corresponding Author	Qiong-Lan Yuan, Professor, Department of Human Anatomy, Histology and Embryology, Tongji University School of Medicine, No. 1239 Siping Road, Yangpu District, Shanghai 200092, China. yqiongl@tongji.edu.cn
Key Words	Neuroplastin 65 protein; Alzheimer’s disease; Neurofibrillary tangles; Amyloid beta; Hippocampus
Core Tip	Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, with pathological hallmarks including intracellular neurofibrillary tangles and extracellular amyloid beta (Aβ) plaques. Synaptic membrane glycoprotein neuroplastin 65 (NP65) has been previously shown to mitigate cognitive impairments and decrease Aβ plaques in the AD mouse model. However, direct evidence linking NP65 expression to AD pathology in human brain remains absent. Our present study shows that NP65 is highly expressed in a wide-range of brain areas and is significantly increased in AD cases. In addition, we found that colocalization of NP65 with neurofibrillary tangles and Aβ plaques in AD brain. Thus, our present study provides the direct evidence for NP65 involved in AD pathology.
Publish Date	2025-05-29 09:14
Citation	<p>Zheng YN, Wang Y, Chen L, Xu LZ, Zhang L, Wang JL, Liu J, Zhang QL, Yuan QL. Increased expression of the neuroplastin 65 protein is involved in neurofibrillary tangles and amyloid beta plaques in Alzheimer’s disease. <i>World J Psychiatry</i> 2025; 15(6): 105751</p>
URL	https://www.wjgnet.com/2220-3206/full/v15/i6/105751.htm
DOI	https://dx.doi.org/10.5498/wjp.v15.i6.105751

Full Article (PDF)	WJP-15-105751-with-cover.pdf
Manuscript File	105751_Auto_Edited_063851.docx
Answering Reviewers	105751-answering-reviewers.pdf
Audio Core Tip	105751-audio.mp3
Biostatistics Review Certificate	105751-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	105751-conflict-of-interest-statement.pdf
Copyright License Agreement	105751-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	105751-foundation-statement.pdf
Institutional Review Board Approval Form or Document	105751-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	105751-non-native-speakers.pdf
Supplementary Material	105751-supplementary-material.pdf
Peer-review Report	105751-peer-reviews.pdf
Journal Editor-in-Chief Review Report	105751-journal-editor-in-chief.pdf
Scientific Misconduct Check	105751-scientific-misconduct-check.png
Scientific Editor Work List	105751-scientific-editor-work-list.pdf
CrossCheck Report	105751-crosscheck-report.pdf