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Articles Published Processes
4/16/2025 5:36:42 AM | Browse: 10 | Download: 29
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Received |
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2025-02-07 04:40 |
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Peer-Review Started |
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2025-02-12 06:45 |
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To Make the First Decision |
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Return for Revision |
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2025-03-10 02:58 |
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Revised |
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2025-03-12 20:00 |
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Second Decision |
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2025-03-24 02:39 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-03-24 09:41 |
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Articles in Press |
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2025-03-24 09:41 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-04-08 09:32 |
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Publish the Manuscript Online |
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2025-04-16 05:36 |
| ISSN |
2220-315x (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Research & Experimental Medicine |
| Manuscript Type |
Basic Study |
| Article Title |
Anti-hypertensive effect of enriched white melon seed protein concentrate biscuit on sodium fluoride exposed rats
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Olamide Wilson Fasakin, Ayoola Awosika, Sanmi Tunde Ogunsanya, Iyanuoluwa Olushola Benson and Akinyode Isaac Olopoda |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ayoola Awosika, Associate Professor, MD, College of Medicine, University of Illinois, 1 Illini drive, Peoria, IL 61601, United States. ayoolaawosika@yahoo.com |
| Key Words |
Hypertension; Sodium fluoride; Sweet orange peels; White melon seed; Protein concentrate |
| Core Tip |
The present study thus evaluates the antihypertensive effect of sweet orange peels-enriched white melon seed protein concentrate (WSP) biscuit meal in sodium fluoride (NaF)-exposed rats. Hypertension is mainly dependent on the biological mechanisms of the heart’s renin-angiotensin-aldosterone system which have also been implicated to be significantly modulated in NaF toxicity. Exposure to NaF also results in hypertension via excessive production of reactive oxygen species, damage of DNA, and depletion of antioxidant defense systems in cardiac tissues. Results obtained showed that NaF administration elevated the collagen content of cardiac tissues, activities of angiotensin-1 converting enzyme and concentrations of cardiac troponin I, creatine kinase-MB, and lactate dehydrogenase, tumor necrosis factor-alpha, and interleukin 1 beta, while there was a reduction in the concentration of nitric oxide and antioxidant; however, their alterations were significantly prevented in WSP biscuits-fed rats. |
| Publish Date |
2025-04-16 05:36 |
| Citation |
<p>Fasakin OW, Awosika A, Ogunsanya ST, Benson IO, Olopoda AI. Anti-hypertensive effect of enriched white melon seed protein concentrate biscuit on sodium fluoride exposed rats. <i>World J Exp Med</i> 2025; 15(2): 105798</p> |
| URL |
https://www.wjgnet.com/2220-315x/full/v15/i2/105798.htm |
| DOI |
https://dx.doi.org/10.5493/wjem.v15.i2.105798 |
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