Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	105887
Country	China

Received	2025-02-10 05:34
Peer-Review Started	2025-02-10 05:34
To Make the First Decision
Return for Revision	2025-03-18 11:06
Revised	2025-03-25 15:20
Second Decision	2025-04-23 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-23 07:04
Articles in Press	2025-04-23 07:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-05-30 03:23
Publish the Manuscript Online	2025-06-13 13:39

ISSN	1948-5204 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Meta-Analysis
Article Title	Transarterial chemoembolization combined with lenvatinib vs transarterial chemoembolization combined with sorafenib for unresectable hepatocellular carcinoma: A systematic review and meta-analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Wei Zhang, Hua Fu, Zi-Rong Liu, Lin Xu, Xu Che, Zheng-Yin Zhan, Yan-Ting Ning and Guo-Chao Zhou
ORCID	Author(s) ORCID Number Wei Zhang http://orcid.org/0000-0002-0936-0817 Xu Che http://orcid.org/0000-0002-1634-4524
Funding Agency and Grant Number	Funding Agency Grant Number the Shenzhen High-Level Hospital Construction Fund, the Sanming Project of Medicine in Shenzhen SZSM202011010 Intramural research projects of Shenzhen Hospital, Cancer Hospital, Chinese Academy of Medical Sciences SZ2020MS010 the Scientific Research Program Fund of Hunan Provincial Health Commission 202204014693
Corresponding Author	Guo-Chao Zhou, Department of Hepatobiliary Surgery, People’s Hospital of Xiangxi Autonomous Prefecture, Intersection of Century Avenue and Jianxin Road, Jishou 416000, Hunan Province, China. zhouguochao5506@sina.com
Key Words	Hepatocellular carcinoma; Lenvatinib; Sorafenib; Transcatheter arterial chemoembolization; Meta-analysis
Core Tip	In this study, we compared the efficacy of transarterial chemoembolization (TACE)-lenvatinib and TACE-sorafenib against unresectable hepatocellular carcinoma. The TACE-lenvatinib group had higher tumor response rate than the TACE-sorafenib group. We also found that both overall survival and progression-free-survival were higher in the TACE-lenvatinib group than in the TACE-sorafenib group. The TACE-lenvatinib group had a higher incidence of hypertension. Therefore, the combination of TACE and lenvatinib resulted in better tumor response rates and survival outcomes in unresectable hepatocellular carcinoma patients compared to TACE-sorafenib, although the former was associated with a higher incidence of hypertension.
Publish Date	2025-06-13 13:39
Citation	<p>Zhang W, Fu H, Liu ZR, Xu L, Che X, Zhan ZY, Ning YT, Zhou GC. Transarterial chemoembolization combined with lenvatinib vs transarterial chemoembolization combined with sorafenib for unresectable hepatocellular carcinoma: A systematic review and meta-analysis. <i>World J Gastrointest Oncol</i> 2025; 17(6): 105887</p>
URL	https://www.wjgnet.com/1948-5204/full/v17/i6/105887.htm
DOI	https://dx.doi.org/10.4251/wjgo.v17.i6.105887

Full Article (PDF)	WJGO-17-105887-with-cover.pdf
PRISMA 2009 Checklist	105887-PRISMA-2009-Checklist.pdf
Manuscript File	105887_Auto_Edited_074736.docx
Answering Reviewers	105887-answering-reviewers.pdf
Audio Core Tip	105887-audio.mp3
Biostatistics Review Certificate	105887-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	105887-conflict-of-interest-statement.pdf
Copyright License Agreement	105887-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	105887-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	105887-non-native-speakers.pdf
Supplementary Material	105887-supplementary-material.pdf
Peer-review Report	105887-peer-reviews.pdf
Scientific Misconduct Check	105887-scientific-misconduct-check.png
Scientific Editor Work List	105887-scientific-editor-work-list.pdf
CrossCheck Report	105887-crosscheck-report.pdf