| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychology, Clinical |
| Manuscript Type |
Case Control Study |
| Article Title |
Clinical manifestations of anxiety and depression in sepsis-associated encephalopathy and multi-omics identification of early biomarker cluster of differentiation 38
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Chun-Rong Wu, Hang-Li Zhu, Yu-Ting Sun, Shi-Hui Shen, Pei-Lin Shi, Yu-Hui Cui, Jian-Guo Tang, Chun-Hui Yang, Shang-Yuan Wang, Xiao-Li Ge and Shu-Ming Pan |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Shanghai Municipal Health Commission Medical New Technology Research and Translation Seed Program |
No. 2024ZZ2052 |
| Scientific Research Project funded by Shanghai Fifth People’s Hospital, Fudan University |
No. 2023WYRH03 |
| Scientific Research Project funded by Shanghai Fifth People’s Hospital, Fudan University |
No. 2025GZRFY05 |
| Shanghai Putuo District Health System Clinical Medicine Discipline Construction Project |
No. 2024tszk01 |
| Shanghai Health System Key Discipline |
No. 2024ZDXK0005 |
| Shanghai Minhang District Health and Family Planning Commission |
No. 2024MWDXK01 |
|
| Corresponding Author |
Shu-Ming Pan, PhD, Professor, Department of Emergency, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 1665 Kongjiang Road, Shanghai 200092, China. panshuming1103@163.com |
| Key Words |
Sepsis-associated encephalopathy; Anxiety; Depression; Cluster of differentiation 38; Metabolomics; Proteomics |
| Core Tip |
Sepsis-associated encephalopathy (SAE) is linked to significant psychiatric symptoms, including anxiety and depression, which worsen patient outcomes. This study integrates multi-omics analysis to identify cluster of differentiation (CD) 38 as a key biomarker associated with nicotinamide adenine dinucleotide (NAD+) metabolism dysregulation in SAE. Elevated CD38 levels correlate with increased psychiatric burden and cognitive decline, suggesting its potential as an early diagnostic marker. A composite biomarker model incorporating CD38 improves SAE prediction accuracy. Targeting NAD+ metabolism may offer novel therapeutic strategies for mitigating neuropsychiatric symptoms in SAE patients. These findings emphasize the need for early psychiatric screening and metabolic interventions in SAE management. |
| Publish Date |
2025-05-29 09:14 |
| Citation |
<p>Wu CR, Zhu HL, Sun YT, Shen SH, Shi PL, Cui YH, Tang JG, Yang CH, Wang SY, Ge XL, Pan SM. Clinical manifestations of anxiety and depression in sepsis-associated encephalopathy and multi-omics identification of early biomarker cluster of differentiation 38. <i>World J Psychiatry</i> 2025; 15(6): 105889</p> |
| URL |
https://www.wjgnet.com/2220-3206/full/v15/i6/105889.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v15.i6.105889 |
