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Articles Published Processes
6/20/2025 8:05:25 AM | Browse: 172 | Download: 621
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Received |
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2025-02-18 02:57 |
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Peer-Review Started |
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2025-02-18 02:57 |
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First Decision by Editorial Office Director |
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2025-03-26 21:23 |
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Return for Revision |
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2025-03-28 09:02 |
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Revised |
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2025-04-11 05:47 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-05-23 02:43 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-05-23 09:59 |
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Articles in Press |
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2025-05-23 09:59 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-06-09 08:33 |
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Publish the Manuscript Online |
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2025-06-20 08:05 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Case Report |
| Article Title |
Durable complete response to sintilimab plus chemotherapy in gallbladder cancer with extensive metastasis: A case report
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Feng Wang, Xin-Lei Gong, Xin-Ni Chen, Zhi-Hui Yang and Xiao-Yuan Chu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Xiao-Yuan Chu, MD, Department of Oncology, Affiliated Jinling Hospital, Medical School of Nanjing University, No. 305, Zhongshan East Road, Xuanwu District, Nanjing 210002, Jiangsu Province, China. chuxiaoyuan00@gmail.com |
| Key Words |
Gallbladder cancer; Immunotherapy; Sintilimab; Complete response; Tumor mutational burden; Extensive metastasis; Case report |
| Core Tip |
We present a rare case of metastatic gallbladder cancer with over sixty liver, lung, and lymph node metastases achieving durable complete remission via sintilimab combined with albumin-bound paclitaxel and cisplatin. Following six cycles, complete response was maintained for over three years, including eleven months post-treatment. High tumor mutational burden (15.4 mutations/megabase) predicted immunotherapy efficacy. This highlights the potential of programmed death-1 inhibitors with chemotherapy in advanced disease and emphasizes tumor mutational burden’s role as a predictive biomarker. |
| Publish Date |
2025-06-20 08:05 |
| Citation |
Wang F, Gong XL, Chen XN, Yang ZH, Chu XY. Durable complete response to sintilimab plus chemotherapy in gallbladder cancer with extensive metastasis: A case report. World J Clin Oncol 2025; 16(6): 105910 |
| URL |
https://www.wjgnet.com/2218-4333/full/v16/i6/105910.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v16.i6.105910 |
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