Publication Name	World Journal of Clinical Oncology
Manuscript ID	105910
Country	China

Received	2025-02-18 02:57
Peer-Review Started	2025-02-18 02:57
To Make the First Decision
Return for Revision	2025-03-28 09:02
Revised	2025-04-11 05:47
Second Decision	2025-05-23 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-23 09:59
Articles in Press	2025-05-23 09:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-06-09 08:33
Publish the Manuscript Online	2025-06-20 08:05

ISSN	2218-4333 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Case Report
Article Title	Durable complete response to sintilimab plus chemotherapy in gallbladder cancer with extensive metastasis: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Feng Wang, Xin-Lei Gong, Xin-Ni Chen, Zhi-Hui Yang and Xiao-Yuan Chu
ORCID	Author(s) ORCID Number Xiao-Yuan Chu http://orcid.org/0009-0006-2382-5533
Funding Agency and Grant Number
Corresponding Author	Xiao-Yuan Chu, MD, Department of Oncology, Affiliated Jinling Hospital, Medical School of Nanjing University, No. 305, Zhongshan East Road, Xuanwu District, Nanjing 210002, Jiangsu Province, China. chuxiaoyuan00@gmail.com
Key Words	Gallbladder cancer; Immunotherapy; Sintilimab; Complete response; Tumor mutational burden; Extensive metastasis; Case report
Core Tip	We present a rare case of metastatic gallbladder cancer with over sixty liver, lung, and lymph node metastases achieving durable complete remission via sintilimab combined with albumin-bound paclitaxel and cisplatin. Following six cycles, complete response was maintained for over three years, including eleven months post-treatment. High tumor mutational burden (15.4 mutations/megabase) predicted immunotherapy efficacy. This highlights the potential of programmed death-1 inhibitors with chemotherapy in advanced disease and emphasizes tumor mutational burden’s role as a predictive biomarker.
Publish Date	2025-06-20 08:05
Citation	<p>Wang F, Gong XL, Chen XN, Yang ZH, Chu XY. Durable complete response to sintilimab plus chemotherapy in gallbladder cancer with extensive metastasis: A case report. <i>World J Clin Oncol</i> 2025; 16(6): 105910</p>
URL	https://www.wjgnet.com/2218-4333/full/v16/i6/105910.htm
DOI	https://dx.doi.org/10.5306/wjco.v16.i6.105910

Full Article (PDF)	WJCO-16-105910-with-cover.pdf
CARE Checklist–2016	105910-CARE-Checklist-2016.pdf
Manuscript File	105910_Auto_Edited_065612.docx
Answering Reviewers	105910-answering-reviewers.pdf
Audio Core Tip	105910-audio.m4a
Conflict-of-Interest Disclosure Form	105910-conflict-of-interest-statement.pdf
Copyright License Agreement	105910-copyright-assignment.pdf
Signed Consent for Treatment Form(s) or Document(s)	105910-informed-consent-statement.pdf
Non-Native Speakers of English Editing Certificate	105910-non-native-speakers.pdf
Peer-review Report	105910-peer-reviews.pdf
Scientific Misconduct Check	105910-scientific-misconduct-check.png
Scientific Editor Work List	105910-scientific-editor-work-list.pdf
CrossCheck Report	105910-crosscheck-report.pdf